本文選題：白細(xì)胞介素- + 白細(xì)胞介素-��； 參考：《廣東醫(yī)學(xué)》2017年14期

【摘要】：目的研究中國新疆地區(qū)維、漢、哈3個(gè)民族白細(xì)胞介素-6(IL-6)和白細(xì)胞介素-10(IL-10)基因多態(tài)性。方法采用SNa Pshot SNP分型技術(shù)檢測中國新疆地區(qū)健康人群(維吾爾族231人、漢族204人、哈薩克族80人)外周血標(biāo)本中IL-6和IL-10基因共6個(gè)位點(diǎn)單核苷酸多態(tài)性(SNP),并進(jìn)行民族間比較。結(jié)果在6個(gè)候選SNP位點(diǎn)中,漢族與維吾爾族和哈薩克族在所有位點(diǎn)(rs1800795、rs1800797、rs1800890、rs1800896、rs1800871和rs1800872)等位基因和基因型頻率分布差異有統(tǒng)計(jì)學(xué)意義(P0.05),維吾爾族與哈薩克族在2個(gè)位點(diǎn)(rs1800795和rs1800797)等位基因和基因型頻率分布差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 IL-6和IL-10基因多態(tài)性在新疆不同民族間分布存在顯著差異。
[Abstract]:Objective to study the polymorphism of interleukin -6 (IL-6) and interleukin -10 (IL-10) gene of 3 ethnic groups in Xinjiang, China. Methods the SNa Pshot SNP typing was used to detect the 6 loci of IL-6 and IL-10 in the peripheral blood samples of the healthy population of Xinjiang, China (231 Uygur, 204 Han, Kazak). Glucoside polymorphism (SNP) and inter ethnic comparison. Results in the 6 candidate SNP loci, the allele and genotype frequency distribution of the Han and Uygur and Kazakh alleles (rs1800795, rs1800797, rs1800890, rs1800896, rs1800871 and rs1800872) were statistically significant (P0.05), and the Uygur and Kazakh people were in 2 sites. There was significant difference in the allele and genotype frequency distribution of the points (rs1800795 and rs1800797) (P0.05). Conclusion the distribution of IL-6 and IL-10 gene polymorphisms was significantly different among different ethnic groups in Xinjiang.

【作者單位】： 廣州醫(yī)科大學(xué)附屬第四醫(yī)院病理科;廣州醫(yī)科大學(xué)附屬第一醫(yī)院病理科;新疆維吾爾自治區(qū)人民醫(yī)院血液科;蘭州軍區(qū)烏魯木齊總醫(yī)院臨床醫(yī)學(xué)研究所;新疆醫(yī)科大學(xué)第二附屬醫(yī)院血液科;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(編號(hào):30860096)
【分類號(hào)】：R394
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本文編號(hào)：1869526