本文選題：基因多態(tài)性 + 精神分裂癥��； 參考：《廣東醫(yī)學(xué)》2017年22期

【摘要】：目的研究miR-137多態(tài)位點(diǎn)rs1625579與精神分裂癥腦白質(zhì)微結(jié)構(gòu)完整性的關(guān)系。方法首發(fā)精神分裂癥患者及性別、年齡、受教育年限配對的健康對照組各32例,進(jìn)行彌散張量成像掃描(DTI),采用基于解剖圖譜的分析(ABA)方法得出腦區(qū)平均各向異性分?jǐn)?shù)(FA)值。抽取靜脈血,采用Sna Pshot方法進(jìn)行基因分型,采用獨(dú)立樣本t檢驗(yàn),比較基因型組間FA值差異。結(jié)果精神分裂癥患者TT與GT+GG基因型的FA值差異均無統(tǒng)計學(xué)意義(P0.05),精神分裂癥患者TT基因型較健康對照者TT基因型右外囊、左外囊、扣帶回、枕額上束、右鉤束、左鉤束FA值顯著降低。結(jié)論精神分裂癥風(fēng)險基因純合子個體可能在右外囊、左外囊、扣帶回、枕額上束、右鉤束、左鉤束存在明顯腦白質(zhì)微結(jié)構(gòu)的完整性下降。
[Abstract]:Objective to study the relationship between miR-137 polymorphism rs1625579 and the microstructural integrity of white matter in schizophrenia. Methods 32 patients with first episode schizophrenia and 32 healthy controls matched with age, age and years of education were examined with diffusion Zhang Liang imaging. The average anisotropic fraction (FAA) of brain was obtained by anatomic map analysis. Venous blood was collected and genotyping was performed by Sna Pshot method. The difference of FA value among genotypes was compared by independent sample t test. Results there was no significant difference in FA values between TT and GT GG genotypes in schizophrenic patients (P 0.05). The right outer capsule, left external capsule, cingulate gyrus, suboccipital bundle, right hook bundle of TT genotype in schizophrenic patients were higher than those in healthy controls. FA value of left hook bundle decreased significantly. Conclusion the homozygous individuals with schizophrenia risk gene may be located in the right outer capsule, left external capsule, cingulate gyrus, supraclavicular bundle, right hook bundle and left hook bundle.
【作者單位】： 湛江市第三人民醫(yī)院精神科;廣東醫(yī)科大學(xué)附屬醫(yī)院放射科;廣東醫(yī)科大學(xué)附屬醫(yī)院精神心理科;
【基金】：湛江市科技計劃項(xiàng)目(編號:2016A01008)
【分類號】：R749.3
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本文編號：1850248