本文選題：胃癌 + 自噬��； 參考：《沈陽(yáng)醫(yī)學(xué)院學(xué)報(bào)》2016年04期

【摘要】：目的:探討自噬相關(guān)基因微管相關(guān)蛋白1輕鏈3(microtubule-associated protein 1 light 3,LC3)和叉頭框蛋白O1(forkhead box protein O1,Fox O1)在胃癌組織中的表達(dá)及其意義。方法:應(yīng)用免疫組織化學(xué)SP法檢測(cè)29例胃癌組織和癌旁正常組織中自噬相關(guān)基因LC3和Fox O1的表達(dá)情況,分析自噬相關(guān)基因表達(dá)水平與臨床病理特征之間的相關(guān)性。結(jié)果:免疫組化結(jié)果提示LC3蛋白、Fox O1蛋白在胃癌組織中的陽(yáng)性表達(dá)率均高于癌旁正常組織(P0.01)。LC3蛋白表達(dá)水平與胃癌的分化程度、淋巴結(jié)轉(zhuǎn)移、臨床分期、侵及胃壁深度明顯相關(guān),與患者的性別、年齡、胃癌發(fā)生部位及大小無(wú)明顯相關(guān)性;Fox O1蛋白表達(dá)水平與胃癌的分化程度明顯相關(guān),與患者的性別、年齡、胃癌發(fā)生部位、大小、淋巴結(jié)轉(zhuǎn)移、臨床分期、侵及胃壁深度無(wú)明顯相關(guān)性。結(jié)論:自噬相關(guān)基因LC3和Fox O1在胃癌組織中表達(dá)水平增高,均與胃癌的分化程度相關(guān),且Fox O1高表達(dá)是胃癌早期頻發(fā)事件,提示自噬活動(dòng)水平的上調(diào)對(duì)胃癌的發(fā)生、發(fā)展具有重要促進(jìn)作用。
[Abstract]:Objective: to investigate the expression and significance of microtubule-associated protein 1 (3(microtubule-associated protein _ 1 light _ 3) and O1(forkhead box protein O _ (1) Fox O _ (1) in gastric carcinoma. Methods: immunohistochemical SP method was used to detect the expression of autophagy associated genes (LC3 and Fox O1) in 29 cases of gastric cancer and adjacent normal tissues, and the correlation between the expression level of autophagy related genes and clinicopathological features was analyzed. Results: the results of immunohistochemistry showed that the positive expression rate of LC3 protein in gastric carcinoma was higher than that in adjacent normal tissues. The expression level of LC3 protein was significantly correlated with the degree of differentiation, lymph node metastasis, clinical stage and depth of gastric wall invasion. There was no significant correlation between the expression of Fox O1 protein and sex, age, location and size of gastric cancer, but also with sex, age, location, size, lymph node metastasis, clinical stage of gastric cancer. There was no significant correlation between the depth of gastric wall invasion. Conclusion: the increased expression of autophagy related genes LC3 and Fox O1 in gastric carcinoma is related to the differentiation of gastric cancer, and the high expression of Fox O1 is a frequent event in the early stage of gastric cancer, suggesting that the upregulation of autophagy activity is associated with the occurrence of gastric cancer. Development plays an important role in promoting development.
【作者單位】： 皖南醫(yī)學(xué)院弋磯山醫(yī)院消化內(nèi)科;皖南醫(yī)學(xué)院弋磯山醫(yī)院病理科;
【分類號(hào)】：R735.2

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