本文選題：P-選擇素 + P-選擇素糖蛋白配體-��； 參考：《臨床神經(jīng)病學(xué)雜志》2017年01期

【摘要】：目的探討P-選擇素(SELP)基因S290N和P-選擇素糖蛋白配體-1(PSGL-1)基因M62I多態(tài)性與缺血性腦梗死的關(guān)系。方法選取148例缺血性腦梗死患者作為腦梗死組,并分為大動(dòng)脈粥樣硬化性(LAA)亞組、心源性腦栓塞(CE)亞組和小動(dòng)脈閉塞性(SAO)亞組;88例正常人群作為正常對(duì)照組。運(yùn)用基因測(cè)序方法檢測(cè)所有受試者SELP基因S290N和PSGL-1基因M62I的基因多態(tài)性。結(jié)果與正常對(duì)照組比較,腦梗死組及其亞組S290N基因型和等位基因頻率差異無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05);腦梗死組M62I基因型和等位基因頻率差異有統(tǒng)計(jì)學(xué)意義(均P0.01);LAA亞組M62I基因型差異無(wú)統(tǒng)計(jì)學(xué)意義(χ~2=5.889,P=0.053),但等位基因頻率差異有統(tǒng)計(jì)學(xué)意義(χ~2=6.156,P=0.021);CE亞組基因型和等位基因頻率差異均無(wú)統(tǒng)計(jì)學(xué)意義(χ~2=1.693,P=0.429;χ~2=1.372,P=0.238);SAO亞組基因型和等位基因頻率差異均有統(tǒng)計(jì)學(xué)意義(χ~2=12.572,P=0.002;χ~2=8.736,P=0.004)。S290N與缺血性腦梗死風(fēng)險(xiǎn)無(wú)相關(guān)性(均P0.05)。M62I顯性模型和超顯性模型與缺血性腦梗死風(fēng)險(xiǎn)有相關(guān)性(OR=2.662,95%CI:1.531~4.630,P=0.000;OR=0.392,95%CI:0.219~0.701,P=0.001),而隱性模型和加性模型與缺血性腦梗死風(fēng)險(xiǎn)無(wú)相關(guān)性(OR=1.428,95%CI:0.528~3.862,P=0.630;OR=2.121,95%CI:0.766~5.872,P=0.156)。結(jié)論 PSGL-1基因M62I多態(tài)性與缺血性腦梗死之間具有相關(guān)性。
[Abstract]:Objective to investigate the relationship between P- selectin S290N and P- selectin glycoprotein ligand-1 PSGL-1) gene M62I polymorphism and ischemic cerebral infarction (ICI). Methods 148 patients with ischemic cerebral infarction were selected as cerebral infarction group and divided into three subgroups: Atherosclerotic subgroup, cardiac cerebral embolism (CEE) subgroup and arteriolar occlusive SAO subgroup (88 normal controls). Gene polymorphisms of SELP gene S290N and PSGL-1 gene M62I were detected by gene sequencing. Results compared with the normal control group, There was no significant difference in the frequency of S290N genotype and allele between cerebral infarction group and its subgroup (all P 0.05), but there was no significant difference in M62I genotype and allele frequency in cerebral infarction group (P 0.01). The allele frequencies were statistically significant (蠂 2 6.156P 0.021) and allele frequencies in CE subgroup were not significantly different (蠂 2 / 2 / 1.693P = 0.429; 蠂 2 / 1.372P 0.238SAO / P = 0.238A / P = 0.002; 蠂 28.738.6P 0.004P 0.004N, P = 0.290N, P = 0.238SAO, respectively) (蠂 212.572P = 0.002; 蠂 28.738.76.6P 0.004P 0.004N) and the risk of ischemic cerebral infarction (蠂 ~ 28.738.6P 0.004N) and the risk of ischemic cerebral infarction (蠂 ~ 28.736.6N / P 0.004N / P _ 290N / P _ (290N) respectively (蠂 ~ 212.572P _ (0.002). There was no correlation between the P0.05).M62I dominant model and the superdominance model and the risk of ischemic cerebral infarction. There was no correlation between the P0.05).M62I dominant model and the risk of ischemic cerebral infarction. There was no correlation between the recessive model and the additive model and the risk of ischemic cerebral infarction. There was no correlation between the two models and the risk of ischemic cerebral infarction. There was no correlation between the model and the risk of ischemic cerebral infarction, but there was no correlation between the recessive model and the additive model and the risk of ischemic cerebral infarction. There was no correlation between the model and the risk of ischemic cerebral infarction, but there was no correlation between the implicit model and the additive model and the risk of ischemic cerebral infarction, and there was no correlation between the recessive model and the additive model and the risk of ischemic cerebral infarction. Conclusion PSGL-1 gene M 62 I polymorphism is associated with ischemic cerebral infarction.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬荊州醫(yī)院檢驗(yàn)醫(yī)學(xué)部;華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬荊州醫(yī)院神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R743.33

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 董釗;石鑄;王璐;陸兵勛;于生元;;高血壓腦出血患者急性期血腫周?chē)M織的炎癥反應(yīng)特征[J];臨床神經(jīng)病學(xué)雜志;2007年04期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李滔;王昌富;梅冰;李琳蕓;姚長(zhǎng)江;龔道凱;胡小輝;;P-選擇素基因S290N和P-選擇素糖蛋白配體-1基因M62I多態(tài)性與缺血性腦梗死臨床關(guān)聯(lián)性研究[J];臨床神經(jīng)病學(xué)雜志;2017年01期

2 孫愷;王，

本文編號(hào)：1803507