本文選題：C反應(yīng)蛋白 + 基因多態(tài)性��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:測(cè)定墨玉縣維吾爾族慢性牙周炎患者和牙周健康對(duì)照者中C反應(yīng)蛋白+1444C/T rs1130864、+1059G/C rs1800947兩位點(diǎn)的基因分型,分析各實(shí)驗(yàn)組間基因型分布和等位基因頻率的差異;探討C反應(yīng)蛋白CRP基因多態(tài)性與維吾爾族人群慢性牙周炎易感性的關(guān)系,為牙周病的防治提供理論依據(jù)和實(shí)驗(yàn)基礎(chǔ)。方法:將墨玉縣維吾爾族人群慢性牙周炎流行病學(xué)調(diào)查組于前期流調(diào)建立的生物樣本庫作為研究對(duì)象,實(shí)驗(yàn)分為健康對(duì)照組、輕度慢性牙周炎組、中重度慢性牙周炎組,每組隨機(jī)抽取100例樣本,提取DNA,采用聚合酶鏈反應(yīng)-限制性片段長度多態(tài)性法測(cè)定rs1800947,rs1130864兩位點(diǎn)的基因分型,統(tǒng)計(jì)分析慢性牙周炎的發(fā)病是否與C-反應(yīng)蛋白基因多態(tài)性相關(guān)。結(jié)果:C反應(yīng)蛋白rs1800947和rs1130864兩多態(tài)性位點(diǎn)的基因型以及等位基因頻率在3組間差異無統(tǒng)計(jì)學(xué)意義(P0.05);有序多分類Logistic回歸分析結(jié)果:年齡是慢性牙周炎發(fā)病的危險(xiǎn)因素(P0.001),性別與慢性牙周炎發(fā)病無顯著相關(guān)(P0.05)。結(jié)論:C反應(yīng)蛋白+1444C/T rs1130864、+1059G/C rs1800947兩位點(diǎn)基因多態(tài)性與墨玉縣維吾爾族成人慢性牙周炎無顯著相關(guān)性,但有必要增加樣本量進(jìn)行進(jìn)一步的探索;年齡是患慢性牙周炎的危險(xiǎn)因素,且年齡越大越易患慢性牙周炎。
[Abstract]:Objective: to determine the genotyping of C-reactive protein 1444C/T rs1130864 and 1059G/C rs1800947 in Uygur patients with chronic periodontitis and healthy controls in Moyu County, and to analyze the difference of genotype distribution and allele frequency among the two groups. To investigate the relationship between C-reactive protein (CRP) gene polymorphism and susceptibility to chronic periodontitis in Uygur population, and to provide theoretical basis and experimental basis for the prevention and treatment of periodontal disease. Methods: the biological sample bank of chronic periodontitis in Uygur population of Moyu County was divided into healthy control group, mild chronic periodontitis group and moderate and severe chronic periodontitis group. DNA was extracted from 100 random samples in each group. The genotyping of rs1800947 rs1130864 was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Whether the incidence of chronic periodontitis was associated with C-reactive protein gene polymorphism was statistically analyzed. Results the genotypes and alleles frequency of rs1800947 and rs1130864 were not significantly different among the three groups, and the results of Logistic regression analysis showed that age was the risk factor of chronic periodontitis (P 0.001). There was no significant correlation between sex and chronic periodontitis. Conclusion there is no significant correlation between the polymorphism of 1444C/T rs1130864 and 1059G/C rs1800947 gene and the chronic periodontitis of Uygur adults in Moyu County, but it is necessary to increase the sample size, and age is the risk factor of chronic periodontitis. And the older the more prone to chronic periodontitis.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R781.4

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本文編號(hào)：1788518