本文選題：肺浸潤性腺癌 + 表皮生長因子受體　； 參考：《福建醫(yī)科大學》2016年碩士論文

【摘要】：目的:探討肺浸潤性腺癌患者表皮生長因子受體(EGFR)基因的突變狀態(tài)與影像學特征、病理亞型等之間的相關性。方法:本文回顧性分析2013年6月到2014年12月之間收治的84例肺浸潤性腺癌病例的臨床資料,所收集的病例均為我院病理確診為肺浸潤性腺癌,并進一步行EGFR基因突變狀態(tài)的檢測,分析肺浸潤性腺癌患者EGFR基因突變狀態(tài)和突變位點與影像學特征、病理亞型等之間的相關性。結果:總體的EGFR基因突變率為70.2%,女性突變率為82.8%,男性突變率為61.2%,兩者之間的差異具有統(tǒng)計學意義(P0.05);CT影像上表現(xiàn)為肺結節(jié)內含磨玻璃影(GGO)成分者突變率為82.8%,CT影像上表現(xiàn)為全實性肺結節(jié)者突變率為59.4%,兩者差異具有統(tǒng)計學意義(P0.05);病理亞型之間:腺泡為主型組突變率為71.7%;貼壁為主型組突變率為83.3%;乳頭為主型組突變率為60.0%;微乳頭為主型突變率100%;實性為主型組的突變率為50.0%,各組之間突變率無明顯差別(P0.05);EGFR基因突變位點與患者性別或影像學上是否含GGO成分無明顯相關性,EGFR基因突變位點在病理分型為貼壁為主型組和腺泡為主型組之間無明顯差異。結論:肺浸潤性腺癌中,EGFR基因在女性、影像學上提示含GGO成分者突變率高,而EGFR基因突變與病理亞型之間無明確關系;EGFR基因的突變位點與性別、影像上是否含GGO成分無明顯相關性,EGFR基因突變位點在病理分型為貼壁為主型組和腺泡為主型組之間無明顯差異。
[Abstract]:Objective: to investigate the relationship between epidermal growth factor receptor (EGFR) gene mutation and imaging features and pathological subtypes in patients with invasive lung adenocarcinoma.Methods: the clinical data of 84 cases of pulmonary infiltrating adenocarcinoma between June 2013 and December 2014 were retrospectively analyzed.The mutation status and mutation site of EGFR gene in patients with lung infiltrating adenocarcinomas were analyzed by detecting the mutation status of EGFR gene, and the correlation between the mutation status of EGFR gene and the imaging features and pathological subtypes were analyzed.Results: the total mutation rate of EGFR gene was 70.2%, female mutation rate was 82.8%, male mutation rate was 61.2%. The difference between them was statistically significant (P 0.05%).The mutation rate was 59.4 in the patients with total solid pulmonary nodules, and the difference was statistically significant (P 0.05); among the pathological subtypes, the mutation rate of the acinar predominant type was 71.7; the adherent type was 83.3%; the nipple dominant type was 60.05; the micropapilla was the micronipple.There was no significant difference between the mutation rate of GGO gene and the sex or imaging of the patients. There was no significant correlation between the mutation rate of EGFR gene and the sex or imaging of the patients.There was no significant difference between adherent type and acinar type.Conclusion: in female patients with invasive lung adenocarcinoma, the mutation rate of GGO gene is high on imaging, but there is no clear relationship between EGFR gene mutation and pathological subtype.There was no significant correlation between the GGO gene mutation and the pathological classification between the adherent type group and the acinar type group, and there was no significant difference between the pathological type and the acinar type group.
【學位授予單位】：福建醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R734.2

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