本文選題：奧卡西平　切入點(diǎn)：Stevens-Johnson綜合征　出處：《中國(guó)藥房》2017年05期 　論文類型：期刊論文

【摘要】：目的:探討奧卡西平致Stevens-Johnson綜合征(SJS)和中毒性表皮壞死松解癥(TEN)的臨床特點(diǎn)及其基因多態(tài)性。方法:計(jì)算機(jī)檢索中國(guó)知網(wǎng)(CNKI)、萬(wàn)方、維普、PubMed、EMBase、SpringerLink等數(shù)據(jù)庫(kù),對(duì)有關(guān)奧卡西平引起嚴(yán)重皮膚不良反應(yīng)的個(gè)案報(bào)道文獻(xiàn)進(jìn)行整理和分析。結(jié)果:收集文獻(xiàn)12篇,獲取奧卡西平引發(fā)SJS/TEN的病例報(bào)道13例。奧卡西平的嚴(yán)重皮膚不良反應(yīng)發(fā)生于男性多于女性,不良反應(yīng)大多發(fā)生在用藥后1~14 d,經(jīng)過(guò)糖皮質(zhì)激素、抗過(guò)敏藥物等治療均能痊愈,沒(méi)有致死性病例報(bào)道。8例患者進(jìn)行了基因型檢測(cè),其中6例患者為HLA-B*1502陽(yáng)性,2例為HLA-B*1518/B*4001(HLA-B*1502的變異)。結(jié)論:應(yīng)當(dāng)嚴(yán)密監(jiān)測(cè)奧卡西平的不良反應(yīng),注意患者用藥教育與隨訪,必要情況下通過(guò)檢測(cè)HLA-B*1502基因可指導(dǎo)臨床合理使用奧卡西平,優(yōu)化臨床用藥方案。
[Abstract]:Objective: to investigate the clinical features and gene polymorphisms of Stevens-Johnson syndrome (SJSS) and toxic epidermal necrolysis (TEN) induced by oxcarbazepine. The case reports of severe skin adverse reactions caused by oxcarbazepine were reviewed and analyzed. Results: 12 articles were collected. A total of 13 cases of SJS/TEN caused by oxcarbazepine were reported. The severe skin adverse reactions of oxcarbazepine occurred in more men than in women, and most of the adverse reactions occurred at 1 to 14 days after treatment, and were cured by glucocorticoids and antiallergic drugs. No fatal cases were reported in which genotypes were detected in 8 patients, of whom 6 were HLA-B*1502 positive and 2 were HLA-B*1518/B*4001(HLA-B*1502 variants. Conclusion: the adverse reactions of oxcarbazepine should be closely monitored, drug education and follow-up should be paid attention to. If necessary, the detection of HLA-B*1502 gene can guide the rational use of oxcarbazepine and optimize the clinical regimen.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院藥學(xué)部;武漢市新洲區(qū)人民醫(yī)院藥學(xué)部;
【基金】：國(guó)家科技支撐計(jì)劃子課題(No.2013BAI06B04)
【分類號(hào)】：R758.59

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本文編號(hào)：1639942