本文選題：奧卡西平　切入點：Stevens-Johnson綜合征　出處：《中國藥房》2017年05期 　論文類型：期刊論文

【摘要】：目的:探討奧卡西平致Stevens-Johnson綜合征(SJS)和中毒性表皮壞死松解癥(TEN)的臨床特點及其基因多態(tài)性。方法:計算機檢索中國知網(wǎng)(CNKI)、萬方、維普、PubMed、EMBase、SpringerLink等數(shù)據(jù)庫,對有關奧卡西平引起嚴重皮膚不良反應的個案報道文獻進行整理和分析。結果:收集文獻12篇,獲取奧卡西平引發(fā)SJS/TEN的病例報道13例。奧卡西平的嚴重皮膚不良反應發(fā)生于男性多于女性,不良反應大多發(fā)生在用藥后1~14 d,經(jīng)過糖皮質激素、抗過敏藥物等治療均能痊愈,沒有致死性病例報道。8例患者進行了基因型檢測,其中6例患者為HLA-B*1502陽性,2例為HLA-B*1518/B*4001(HLA-B*1502的變異)。結論:應當嚴密監(jiān)測奧卡西平的不良反應,注意患者用藥教育與隨訪,必要情況下通過檢測HLA-B*1502基因可指導臨床合理使用奧卡西平,優(yōu)化臨床用藥方案。
[Abstract]:Objective: to investigate the clinical features and gene polymorphisms of Stevens-Johnson syndrome (SJSS) and toxic epidermal necrolysis (TEN) induced by oxcarbazepine. The case reports of severe skin adverse reactions caused by oxcarbazepine were reviewed and analyzed. Results: 12 articles were collected. A total of 13 cases of SJS/TEN caused by oxcarbazepine were reported. The severe skin adverse reactions of oxcarbazepine occurred in more men than in women, and most of the adverse reactions occurred at 1 to 14 days after treatment, and were cured by glucocorticoids and antiallergic drugs. No fatal cases were reported in which genotypes were detected in 8 patients, of whom 6 were HLA-B*1502 positive and 2 were HLA-B*1518/B*4001(HLA-B*1502 variants. Conclusion: the adverse reactions of oxcarbazepine should be closely monitored, drug education and follow-up should be paid attention to. If necessary, the detection of HLA-B*1502 gene can guide the rational use of oxcarbazepine and optimize the clinical regimen.
【作者單位】： 華中科技大學同濟醫(yī)學院附屬協(xié)和醫(yī)院藥學部;武漢市新洲區(qū)人民醫(yī)院藥學部;
【基金】：國家科技支撐計劃子課題(No.2013BAI06B04)
【分類號】：R758.59

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