本文選題：PTPN22　切入點(diǎn)：C1858T　出處：《華中科技大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:應(yīng)用Meta分析系統(tǒng)評價PTPN22 C1858T基因多態(tài)性與系統(tǒng)性紅斑狼瘡的易感性之間的關(guān)系,以及其與狼瘡性腎炎之間的關(guān)系。方法:計(jì)算機(jī)檢索Pubmed、Embase、中國知網(wǎng)(CNKI)、萬方數(shù)據(jù)庫、CBMDisc,檢索截止日期為2016年2月17日,全面收集國內(nèi)外發(fā)表的關(guān)于PTPN22 C1858T基因多態(tài)性與系統(tǒng)性紅斑狼瘡的流行病學(xué)文獻(xiàn)。嚴(yán)格按照所制定的納入/排除標(biāo)準(zhǔn)篩選文獻(xiàn),并對符合納入標(biāo)準(zhǔn)的文獻(xiàn)進(jìn)行數(shù)據(jù)提取,采用NOS標(biāo)準(zhǔn)(The Newcastle-Ottawa Scale)評價納入文獻(xiàn)的質(zhì)量。應(yīng)用STATA 12.0軟件對提取的數(shù)據(jù)進(jìn)行Meta分析,采取比值比(Odds ratio,OR)和95%CI可信區(qū)間(confidence interval,CI)作為合并效應(yīng)量評價PTPN22 C1858T與SLE易感性之間關(guān)系的關(guān)聯(lián)強(qiáng)度,通過Begg’s漏斗圖和Egger直線回歸法評估發(fā)表偏倚。敏感性分析采用逐個排除研究的方法評價結(jié)果的穩(wěn)定性。結(jié)果:共納入16個研究,包括3143例SLE患者,6980例對照,5種遺傳模型Meta分析結(jié)果均顯示PTPN22 C1858T基因多態(tài)性與SLE易感性相關(guān)(等位基因模型OR=1.64,95%CI=1.41-1.91;顯性遺傳模型OR=1.60,95%CI=1.42-1.81;隱性遺傳模型OR=2.03,95%CI=1.35-3.05;純合子模型OR=2.20,95%CI=1.46-3.32;雜合子模型OR=1.57,95%CI=1.39-1.77)�；诜N族的亞組分析發(fā)現(xiàn),PTPN22 C1858T基因多態(tài)性與歐洲人、西班牙人、阿拉伯人的SLE易感性相關(guān);而未有證據(jù)顯示與亞洲人群相關(guān)。該基因多態(tài)性與SLE合并狼瘡性腎炎的相關(guān)性分析顯示PTPN22 C1858T基因多態(tài)性可能與系統(tǒng)性紅斑狼瘡患者并發(fā)狼瘡性腎炎的危險性相關(guān)(顯性遺傳模型:OR=1.65,95%CI=1.19-2.30)。結(jié)論:PTPN22 C1858T基因多態(tài)性與系統(tǒng)性紅斑狼瘡的易感性有關(guān);PTPN22 C1858T基因多態(tài)性可能與系統(tǒng)性紅斑狼瘡患者并發(fā)狼瘡性腎炎的危險性相關(guān)。
[Abstract]:Objective: to evaluate the relationship between PTPN22 C1858T gene polymorphism and susceptibility to systemic lupus erythematosus by Meta analysis system. Methods: Pubmed Embase, CNKI and CBM Disc were searched by computer, and the deadline of search was February 17th 2016. To collect the epidemiological literature about PTPN22 C1858T gene polymorphism and systemic lupus erythematosus published at home and abroad. The NOS standard was used to evaluate the quality of the Newcastle-Ottawa scale. The Meta analysis of the extracted data was carried out by using STATA 12.0 software, and the ratio ratio of odds ratio (OR) and 95CI confidence confidence interval-cience were used as the combined effects to evaluate the correlation between PTPN22 C1858T and SLE susceptibility, and the correlation between PTPN22 C1858T and SLE susceptibility was evaluated by using STATA 12.0 software. The bias of publication was evaluated by Begg's funnel graph and Egger linear regression. Sensitivity analysis was used to evaluate the stability of the results by one exclusion study. Results: a total of 16 studies were included. The results of Meta analysis of 5 genetic models including 3 143 SLE patients and 6 980 controls showed that the polymorphism of PTPN22 C1858T gene was associated with the susceptibility to SLE (allelic model OR1. 644 / 95 CI 1.41-1.91; dominant genetic model OR1. 6095CII 1.42-1.81; recessive genetic model OR2.039 95CII 1.35-3.05; homozygote model OR1. 20995 CI1.46-3.32; heterozygote model OR2.20995 CI1.46-3.32; dominant genetic model OR1. 6095CI1: 1.42-1.81; recessive genetic model OR2.039 95CI1. 35-3.05; homozygous model OR2.209595 CI1.46-3.32; The Race based subgroup analysis showed that the polymorphism of PTPN22 C1858T gene was associated with that of Europeans. The SLE susceptibility of Spaniards and Arabs was related; There is no evidence of association with Asian population. The association between the polymorphism of the gene and SLE with lupus nephritis suggests that the polymorphism of PTPN22 C1858T gene may be associated with the risk of lupus nephritis in patients with systemic lupus erythematosus. (dominant genetic model: OR1.165 / 95) 1.19-2.300.Conclusion the polymorphism of the 1: PTPN22 C1858T gene is associated with the susceptibility of systemic lupus erythematosus to systemic lupus erythematosus. The polymorphism of PTPN22 C1858T gene may be associated with the risk of lupus nephritis in patients with systemic lupus erythematosus.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R593.241

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