本文選題：胃潰瘍　切入點：MDR　出處：《貴州醫(yī)藥》2016年11期 　論文類型：期刊論文

【摘要】：目的分析MDR1C3435T基因多態(tài)性與胃潰瘍患者治療的相關性。方法回顧性分析2010年10月至2015年10月來我院就診的胃潰瘍患者共80名,其中Hp陽性患者47例,另選取80例健康體檢者作為對照組,測定兩組入選對象MDR1C3435T基因多態(tài)性,比較不同基因型胃潰瘍患者治療后Hp陽性率和耐藥率。結果觀察組(Hp陽性)患者3435TT基因型頻率和T等位基因頻率均明顯高于觀察組(Hp陰性)和對照組(P0.05);觀察組(Hp陰性)患者3435TT基因型頻率和T等位基因頻率亦均明顯高于對照組(P0.05)。治療后3435TT基因型患者Hp陽性率和耐藥率均明顯高于C3435T和CC3435基因型患者(P0.05)。結論 MDR1C3435T基因多態(tài)性與胃潰瘍患者的治療具有相關性,3435TT基因型患者較難根除Hp,耐藥性較強。
[Abstract]:Objective to analyze the relationship between the polymorphism of MDR1C3435T gene and the treatment of gastric ulcer. Methods from October 2010 to October 2015, there were 80 patients with gastric ulcer, 47 of whom were HP positive. In addition, 80 healthy persons were selected as control group, and the polymorphism of MDR1C3435T gene was measured in the two groups. Results the frequency of 3435TT genotype and T allele in patients with different genotypes of gastric ulcer after treatment were significantly higher than those in control group (P 0.05). The frequency of 3435TT genotype and T allele were significantly higher in patients with 3435TT than those in control group (P 0.05). The HP positive rate and drug resistance rate in patients with 3435TT genotype after treatment were significantly higher than those in patients with C3435T and CC3435 genotypes (P 0.05). Conclusion the polymorphism of MDR1C3435T gene in patients with C3435TT genotype is higher than that in patients with C3435T genotype and CC3435 genotype. The treatment of gastric ulcer patients is more difficult to eradicate HpT and drug resistance is stronger in the patients with allele 3435TT genotype.
【作者單位】： 常州市中醫(yī)醫(yī)院消化內(nèi)科;
【分類號】：R573.1

【相似文獻】

相關期刊論文 前10條

1 漆以芹;;胃潰瘍患者血清TGF-β_1和T淋巴細胞亞群檢測的臨床意義[J];放射免疫學雜志;2010年02期

2 程會昌;;胃潰瘍患者的手術治療與保守治療臨床效果[J];當代醫(yī)學;2011年03期

3 周成林;;60例胃潰瘍患者臨床治療分析[J];當代醫(yī)學;2012年04期

4 楊瑩瑩;;40例胃潰瘍患者的針對性治療療效觀察[J];現(xiàn)代診斷與治療;2012年12期

5 馮根養(yǎng);趙超;肖|∶，

本文編號：1579355