本文選題：抑郁癥　切入點(diǎn)：GNβ3　出處：《重慶醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：背景:有研究發(fā)現(xiàn)G蛋白β3基因(GNβ3)通過(guò)影響幾種神經(jīng)遞質(zhì)受體的胞內(nèi)轉(zhuǎn)導(dǎo)而與精神疾病相關(guān)。一些研究探討了GNβ3基因的C825T多態(tài)性(GNβ3C825T)與抑郁和抗抑郁治療反應(yīng)的關(guān)系,然而就目前的研究而言,GNβ3C825T與抑郁癥之間的關(guān)系仍然不一致。因此,我們?cè)噲D通過(guò)Meta分析發(fā)現(xiàn)GNβ3C825T作為抑郁癥危險(xiǎn)因素對(duì)抑郁癥易感性的影響。方法:根據(jù)PRISMA聲明(系統(tǒng)綜述和薈萃分析優(yōu)先報(bào)告的條目)的要求開展本次Meta分析。我們系統(tǒng)檢索了1990年1月至2014年9月期間Pub Med,Scopus,Science Direct,Springer,Embase,psy INFO和CNKI收錄的所有已發(fā)表的GNβ3C825T與抑郁癥關(guān)聯(lián)的研究。通過(guò)比值比(OR)及其95%置信區(qū)間(CI)評(píng)估GNβ3C825T與抑郁風(fēng)險(xiǎn)之間的關(guān)聯(lián)。計(jì)算了等位基因比較(C與T),純合子(CC與TT)模型,雜合子(CC與CT)模型,顯性模型(CC+CT與TT)和隱性模型(CC與TT+CT)的OR合并值,另外根據(jù)種族進(jìn)行了亞組分析。為了評(píng)估各模型的潛在偏倚,通過(guò)留一法研究來(lái)進(jìn)行靈敏度分析來(lái)評(píng)估每個(gè)研究對(duì)合并值的影響。結(jié)果:共篩選出9個(gè)病例對(duì)照研究,包含1055例抑郁癥患者和1325例健康對(duì)照者。分析發(fā)現(xiàn)等位基因模型下GNβ3 C825T的T等位基因OR合并值與抑郁風(fēng)險(xiǎn)顯著相關(guān),同時(shí)在顯性模型、隱性模型、雜合子模型下也觀察到GNβ3C825T的T等位基因與抑郁風(fēng)險(xiǎn)之間的顯著關(guān)聯(lián)。GNβ3C825T的T等位基因可增加抑郁癥的易感性。種族亞組分析發(fā)現(xiàn)亞洲種群存在該關(guān)聯(lián),而高加索人中沒(méi)有發(fā)現(xiàn)該關(guān)聯(lián)。結(jié)論:本研究為揭示GNβ3C825T與抑郁癥關(guān)系的第一個(gè)Meta分析。我們發(fā)現(xiàn)亞洲人中GNβ3C825T的T等位基因攜帶者更容易患抑郁癥。相比之下,高加索人中GNβ3C825T的T等位基因攜帶者和抑郁風(fēng)險(xiǎn)之間沒(méi)有顯著的相關(guān)性。這些結(jié)果可能會(huì)為臨床醫(yī)生和公共衛(wèi)生管理人員提供評(píng)估抑郁癥的重要篩查工具。
[Abstract]:Background: it has been found that G protein 尾 3 gene (GN 尾 3) is associated with mental illness by affecting intracellular transduction of several neurotransmitter receptors. Some studies have explored the relationship between the C825T polymorphism of GN 尾 3 gene and depression and antidepressant response. However, the relationship between GN 尾 3C825T and depression is still inconsistent in current studies. We try to find out the influence of GN 尾 3C825T as a risk factor of depression on the susceptibility of depression through Meta analysis. Methods: to carry out this Meta analysis according to the requirements of the PRISMA statement (the items of systematic review and meta-analysis priority report). We systematically searched all published studies on the association of GN 尾 3C825T with depression recorded by Pub Medus Scopus Science Direct Spring INFO and CNKI between January 1990 and September 2014. The association between GN 尾 3C825T and depression risk was assessed by ratio ratio ratio and its 95% confidence interval. The allelic comparison models of C and TX, homozygote CC and TTT were calculated. In order to evaluate the potential bias of each model, the combined OR values of CC and CTS models, dominant model CCCT and TTT) and recessive model of CC and TT CTs were analyzed by subgroup analysis according to race, in order to evaluate the potential bias of each model. A sensitivity analysis was conducted to assess the impact of each study on the combined value. Results: nine case-control studies were selected. There were 1055 patients with depression and 1325 healthy controls. The results showed that the combination of T allele OR of GN 尾 3C825T was significantly correlated with the risk of depression in the dominant model and recessive model. A significant association between the T allele of GN 尾 3C825T and the risk of depression was also observed under heterozygote model. The T allele of GN 尾 3C825T increased the susceptibility to depression. Conclusion: this study was the first Meta analysis to reveal the relationship between GN 尾 3C825T and depression. We found that the T allele carriers of GN 尾 3C825T were more likely to develop depression in Asian population. There was no significant correlation between T allele carriers of GN 尾 3C825T and risk of depression in Caucasians. These results may provide clinicians and public health administrators with an important screening tool for assessing depression.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R749.4

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相關(guān)期刊論文 前1條

1 肖紅,姚輝,郭蘇皖,李箕軍,吳如金;Gβ3基因C825T多態(tài)性與抗抑郁藥的臨床療效[J];中國(guó)臨床藥學(xué)雜志;2003年02期

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本文編號(hào)：1576946