本文選題：前列腺腫瘤　切入點：p基因　出處：《重慶醫(yī)學》2017年25期 　論文類型：期刊論文

【摘要】：目的利用Meta分析的方法系統(tǒng)評價p53基因codon72多態(tài)性與亞洲人群前列腺癌發(fā)病風險的關系。方法檢索PubMed、Medline、Ovid、萬方和CNKI數據庫,篩查p53基因codon72多態(tài)性位點與亞洲人群前列腺癌易感性關聯的病例-對照研究。采用Stata 12.0軟件對獲得的各項研究數據進行統(tǒng)計分析,并評估數據的可靠性和統(tǒng)計文獻的發(fā)表偏倚等。結果 Meta分析顯示,p53基因codon72多態(tài)性與亞洲人群前列腺癌發(fā)病風險無明顯相關性。對對照組來源進行亞組分析結果顯示,基于醫(yī)院來源的亞組,codon72多態(tài)性在P vs.A[OR=0.680,95%CI(0.546,0.847),P=0.001]、PP vs.AA[OR=0.409,95%CI(0.260,0.645),P=0.000]、PA+PP vs.AA[OR=0.513,95%CI(0.350,0.749),P=0.001]等模型中均能顯著降低亞洲人群的前列腺癌易感性。然而,在對照組來源基于普通人群的亞組中,codon72多態(tài)性位點在PAvs.AA[OR=1.664,95%CI(1.272,2.177),P=0.000]和PA+PP vs.AA[OR=1.314,95%CI(1.020,1.693),P=0.003 6]的基因型中卻增加了亞洲人群前列腺癌發(fā)生的危險性。根據是否符合HWE平衡進行了亞組分析,結果發(fā)現,在不符合HWE平衡的亞組中,p53基因codon72多態(tài)性在PP vs.AA[OR=0.251,95%CI(0.135,0.467),P=0.000]和PA+PP vs.AA[OR=0.564,95%CI(0.330,0.964),P=0.036]的基因型中是降低亞洲人群前列腺癌易感性的一個保護因素。結論 p53基因codon72多態(tài)性與亞洲人群前列腺癌易感性無關。
[Abstract]:Objective to systematically evaluate the relationship between p53 gene codon72 polymorphism and the risk of prostate cancer in Asian population by Meta analysis. Methods PubMedMedline Ovid, Wanfang and CNKI databases were searched. A case-control study on the association of p53 gene codon72 polymorphism with the susceptibility to prostate cancer in Asian population. The data obtained were statistically analyzed by Stata 12.0 software. Results Meta analysis showed that there was no significant correlation between p53 gene codon72 polymorphism and the risk of prostate cancer in Asian population. The polymorphisms of codon72 in subgroup based on hospital origin can significantly reduce the susceptibility to prostate cancer in the models of P vs.A [OR0.680C95CII 0.5460.47P0. 001] PP vs.AA [OR0.40995 CIQ 0.2600.2645 P0.000] PA PP vs.AA [OR0.51395CI0.350 0.749P0.001]. However, there was no significant difference in the risk of prostate cancer in Asian population. The polymorphisms of codon72 locus in the subgroup of the control group based on the general population increased the risk of prostate cancer in Asian population according to the subgroup analysis of PAvs.AA [OR1. 664 / 95CII 1.272 / 2.177] and PA PP vs.AA [OR1. 31495 / CI1.020 / 1.693P0. 0036]. A subgroup analysis was carried out according to the HWE balance. The p53 gene codon72 polymorphism was a protective factor in the genotypes of PP vs.AA (ORR 0.255) and PA PP vs.AA (OR0.56495) and PA PP vs.AA (0.3300.964). Conclusion p53 gene codon72 polymorphism is not associated with the susceptibility of Asian population to prostate cancer. [conclusion] there is no correlation between p53 gene codon72 polymorphism and the susceptibility of Asian population to prostate cancer. [conclusion] there is no relationship between p53 gene codon72 polymorphism and the susceptibility of Asian population to prostate cancer.
【作者單位】： 吉林醫(yī)藥學院附屬醫(yī)院泌尿外科;
【分類號】：R737.25

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