本文關鍵詞： 腦梗死 胱硫醚β合酶 同型半胱氨酸 認知功能障礙　出處：《中風與神經(jīng)疾病雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的研究同型半胱氨酸(homocystine,Hcy)代謝基因胱硫醚β合酶(cystathionineβsynthase,CBS)基因T833C突變在急性腦梗死后輕度血管性認知功能障礙(vascular cognitve impairment,VCI)中的價值研究。方法采用擴增阻滯突變體系法檢測CBS T833C基因型,對急性腦梗死分別行入院時、14 d、30 d和90 d時蒙特利爾認知評估量表(Montreal Cognitive Assessment,Mo CA)和簡易精神狀態(tài)量表(Mini-Mental State Examination,MMSE)評分。結果 Logistic回歸分析顯示Hcy可能是輕度VCI的獨立危險因素(OR為1.274;95%CI 1.027~1.264,P=0.018);空腹高同型半胱氨酸血癥(Hhcy)組14 d、30 d和90 d MMSE和Mo CA評分分別低于Hcy水平正常組(P0.01或0.05);各基因型入院時MMSE和Mo CA評分無差別(P0.05),而入院14 d時,C/C型MMSE和Mo CA評分低于T/T型(P0.05),隨訪30 d和90 d時,C/C型MMSE和Mo CA評分趨勢是低于C/T和T/T型(P0.01或0.05),C/T型低于T/T型(P0.01或0.05)。結論 CBS T833C基因突變可能是引起Hhcy,間接促進了腦梗死患者VCI事件的出現(xiàn),可能是VCI的遺傳易感因素。
[Abstract]:Objective to study the value of cystathionine 尾 synthase (T833C) mutation in homocystine homocystine homocystin (HCH) metabolism gene in patients with mild vascular cognitive impairment (cognitve) after acute cerebral infarction. Methods the genotype of CBS T833C was detected by amplified block mutation system. The acute cerebral infarction was evaluated with the Montreal Cognitive Assessment scale (Hcy) and the Mini-Mental State examination scale (MMSE) on the 14th day and the 90th day after admission respectively. Results the Logistic regression analysis showed that Hcy might be an independent risk of mild VCI. The OR was 1.274 / 95 / CI 1.027 / 1.264g / h 0.018; the scores of MMSE and Mo CA in fasting hyperhomocysteinemia group were lower than those in normal Hcy group (P0.01 or 0.05) on day 14, respectively, and there was no difference in MMSE and Mo CA scores between different genotypes on admission, but on the 14th day after admission, the scores of C / C MMSE were significantly lower than those of normal Hcy group (P < 0.01 or 0.05), but on the 14th day after admission, the scores of C / C MMSE were not significantly different from those of control group (P < 0.05). The tendency of C / C MMSE and Mo CA score was lower than that of C / T and T / T / T / T / P / T / P / T / P / T / P / T / P / T respectively. Conclusion the mutation of CBS T833C gene may be the cause of HHcy1 or 0.05% of T / T / T / T / T group. Conclusion the mutation of CBS T833C gene may be a cause of HHcy. it may indirectly promote the development of cerebral infarction. The emergence of the VCI event, It may be the genetic predisposing factor of VCI.
【作者單位】： 天津醫(yī)科大學第二醫(yī)院神經(jīng)內(nèi)科;天津醫(yī)科大學第二醫(yī)院檢驗科;
【基金】：天津市衛(wèi)計委科技基金(2015KZ095)
【分類號】：R743.33

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