本文關(guān)鍵詞： 哮喘 代謝綜合征 瘦素 瘦素受體 基因多態(tài)性　出處：《中國免疫學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的:探討瘦素受體基因Gln223Arg位點多態(tài)性與哮喘和代謝綜合征之間的關(guān)系。方法:選擇120例哮喘病人(A)、92例代謝綜合征病人(M)、54例哮喘合并代謝綜合征病人(A+M)和81例健康對照者(NC),其中哮喘組根據(jù)肺功能進(jìn)一步分為輕-中度哮喘組和重度哮喘組。應(yīng)用聚合酶鏈反應(yīng)-限制性內(nèi)切酶片段長度多態(tài)性(PCR-RFLP)方法測定所有受試者瘦素受體基因Gln223Arg位點基因型,ELISA法檢測血清瘦素濃度,同時測定所有受試者BMI、血壓、肺功能及空腹血糖。結(jié)果:(1)代謝綜合征組和哮喘合并代謝綜合征組AA+AG基因型和A等位基因頻率較健康對照組顯著性增高(P0.05);(2)哮喘組中重度持續(xù)組AA+AG基因型和A等位基因頻率較健康對照組顯著增高(P0.05);(3)AA+AG基因型的血漿瘦素濃度、MBI、收縮壓與GG基因型比均顯著升高,FEV1%、FEV1/FVC明顯下降(P0.05)。結(jié)論:瘦素受體Gln223Arg位點基因多態(tài)性與哮喘和代謝綜合征具有相關(guān)性,其中A等位基因可能通過瘦素抵抗誘導(dǎo)哮喘和代謝綜合征的發(fā)生,是哮喘和代謝綜合征的共同遺傳易感因子。
[Abstract]:Objective: to investigate the relationship between leptin receptor gene Gln223Arg polymorphism and asthma and metabolic syndrome. There were 92 patients with metabolic syndrome and 54 patients with asthma complicated with metabolic syndrome. Asthma group was further divided into mild to moderate asthma group and severe asthma group according to lung function. Polymerase chain reaction-restriction endonuclease fragment length polymorphism (PCR-RFLP) was used. Methods the Gln223Arg genotype of leptin receptor gene was determined in all subjects. The serum leptin concentration was measured by ELISA method, and the blood pressure and BMIs of all the subjects were also measured at the same time. Results the frequency of AA AG genotype and A allele in the metabolic syndrome group and asthma combined metabolic syndrome group was significantly higher than that in the healthy control group (P 0.05). (2) the frequency of AA AG genotype and A allele in moderate and severe persistent asthma group was significantly higher than that in healthy control group (P 0.05). The plasma leptin concentration and the ratio of systolic blood pressure to GG genotype were significantly increased by 1% of FEV1 in the plasma leptin concentration and the ratio of systolic blood pressure (SBP) to GG genotype in the AA AG genotype. Conclusion: the polymorphism of leptin receptor Gln223Arg gene is associated with asthma and metabolic syndrome. Allele A may induce the occurrence of asthma and metabolic syndrome through leptin resistance and is the common genetic susceptibility factor of asthma and metabolic syndrome.
【作者單位】： 青島市市立醫(yī)院干部保健科;青島大學(xué)附屬醫(yī)院;
【分類號】：R562.25;R589
【正文快照】： (1)青島大學(xué)附屬醫(yī)院,青島266002。支氣管哮喘是一種多基因遺傳性疾病,其疾病的發(fā)生和進(jìn)展受遺傳和環(huán)境等多種因素影響,機制復(fù)雜,目前尚未完全闡明。近年來人們發(fā)現(xiàn),肥胖患者的哮喘發(fā)病率較正常體重者明顯升高[1,2]。瘦素是人體內(nèi)影響能量代謝和體重的重要激素。研究表明,瘦素

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