發(fā)布時(shí)間：2018-01-25 00:01

  本文關(guān)鍵詞： 去甲腎上腺素轉(zhuǎn)運(yùn)體 TC 多態(tài)性 抑郁癥 Meta分析　出處：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2017年10期 　論文類型：期刊論文

【摘要】：目的:采用Meta分析探討去甲腎上腺素轉(zhuǎn)運(yùn)體(norepinephrine transporter,NET)T182C基因多態(tài)性與抑郁癥易感性之間的關(guān)系。方法:通過檢索Pub Med、Embase、萬方數(shù)據(jù)庫、維普中文科技期刊數(shù)據(jù)庫、中國知網(wǎng)(Chinese National Knowledge Infrastructure,CNKI)數(shù)據(jù)庫,獲取相關(guān)研究,提取有效數(shù)據(jù)后,采用STATA 12.0進(jìn)行統(tǒng)計(jì)分析。評價(jià)指標(biāo)采用比值比(odds ratio,OR)、95%可信區(qū)間(confidence interval,CI)與P值,計(jì)算4種不同遺傳模型下T182C基因多態(tài)性與抑郁癥發(fā)病風(fēng)險(xiǎn)的關(guān)聯(lián)性。結(jié)果:共檢索出12篇符合標(biāo)準(zhǔn)的文獻(xiàn)進(jìn)入Meta分析,包括病例組3 056例,對照組2 861例。在等位(OR=1.15,95%CI=1.04~1.28,P=0.009)、共顯性(OR=1.41,95%CI=1.04~1.90,P=0.026)、隱性(OR=1.44,95%CI=1.13~1.85,P=0.004)3種遺傳模式下T182C位點(diǎn)多態(tài)性與抑郁癥易感性的關(guān)系具有統(tǒng)計(jì)學(xué)意義,且等位基因C或基因型CC增加抑郁癥發(fā)病風(fēng)險(xiǎn)。亞組分析發(fā)現(xiàn)采用不同的評價(jià)量表是異質(zhì)性的主要來源。結(jié)論:NET T182C基因多態(tài)性與抑郁癥的發(fā)生有關(guān),等位基因C是導(dǎo)致抑郁癥發(fā)生的一個潛在危險(xiǎn)因素。
[Abstract]:Objective: to investigate the norepinephrine transporter, a norepinephrine transporter, by Meta analysis. The relationship between NET)T182C gene polymorphism and susceptibility to depression. Methods: to search the database of Pub Medbase, Wanfang database and Weipu Chinese science and technology journal. The Chinese National Knowledge Infrastructure (CNKI) database is used to obtain relevant research. After extracting valid data, STATA 12.0 was used for statistical analysis. 95% confidence interval confidence intervalescence) and P value. The association of T182C gene polymorphisms with the risk of depression was calculated under four different genetic models. Results: a total of 12 articles were retrieved for Meta analysis. There were 3 056 cases in the case group and 2 861 cases in the control group. Co-dominant OR1. 41 and 95% CI1. 04 + 1. 90 P0. 026, recessive OR1. 4 4 + 95% CI1. 131. 85. The relationship between the polymorphism of T182C locus and the susceptibility to depression was statistically significant. Allele C or genotype CC increased the risk of depression. Subgroup analysis showed that different evaluation scales were the main source of heterogeneity. Conclusion: net. The polymorphism of T182C gene is associated with the occurrence of depression. Allele C is a potential risk factor for depression.
【作者單位】： 川北醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院生物化學(xué)教研室;川北醫(yī)學(xué)院影像系;
【基金】：四川省教育廳項(xiàng)目基金資助項(xiàng)目(編號:09ZA040)
【分類號】：R749.4
【正文快照】： 抑郁癥是精神科的常見疾病之一,其發(fā)病機(jī)制至今未明,但普遍認(rèn)為遺傳因素與抑郁癥的發(fā)生發(fā)展密切相關(guān)。研究表明,去甲腎上腺素(norepinephrine,NE)主要參與覺醒、情感、意識、食欲、性欲等生理功能,在抑郁癥的發(fā)病中可能起著重要作用。NE是通過NET的微調(diào)而發(fā)揮不同作用的:去甲

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