【摘要】：在自然界病毒衣殼及籠狀蛋白質(zhì)大分子結(jié)構(gòu)的啟發(fā)下,運(yùn)用V型雙齒橋連吡啶配體和具有平面四方構(gòu)型的Pd2+離子的溶液配位自組裝,一系列具有MnL2n經(jīng)驗(yàn)分子式的多組分巨大中空"納米容器"型超分子結(jié)構(gòu)被成功構(gòu)筑。通過在配體內(nèi)外引入官能團(tuán)的策略,可以簡(jiǎn)單地實(shí)現(xiàn)衣殼骨架結(jié)構(gòu)的內(nèi)外功能化。內(nèi)功能化后的"納米容器"具有特殊的高密度相,不僅可以實(shí)現(xiàn)對(duì)不同類型客體分子的包裹,而且可以作為"納米反應(yīng)器"實(shí)現(xiàn)尺寸均一可控納米粒子的原位合成以及小分子的催化轉(zhuǎn)化。外功能化的核殼結(jié)構(gòu)則可以對(duì)寡肽、DNA等生物分子具有特定的識(shí)別作用。本文對(duì)此類"納米容器"型超分子的設(shè)計(jì)原理、自組裝合成與表征、以及功能化應(yīng)用等方面進(jìn)行了綜述。
[Abstract]:under the light of the large molecular structure of the natural virus capsid and the cage-shaped protein, the V-type double-tooth bridge and the solution of the Pd2 + ion with the planar tetragonal configuration are coordinated and self-assembled, A series of multi-component, large hollow "nano-container"-type supramolecular structures with MnL2n empirical formula are successfully constructed. The internal and external functionalization of the shell framework structure can be realized simply by the strategy of introducing functional groups inside and outside the ligand. The functionalized nano-container has a special high-density phase, not only can realize the encapsulation of different types of guest molecules, but also can be used as a nano-reactor to realize in-situ synthesis of controllable nano-particles and catalytic conversion of small molecules. The external functionalized core-shell structure can have specific identification effect on the oligopeptide, the DNA and other biological molecules. This paper reviews the design principle, self-assembly and characterization of such "nano-container"-type supermolecules, and the functional application.
【作者單位】： 中國科學(xué)院福建物質(zhì)結(jié)構(gòu)研究所;中國科學(xué)院大學(xué);
【基金】：國家自然科學(xué)基金項(xiàng)目(No.21402201)資助~~
【分類號(hào)】：O641.3

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本文編號(hào)：2523101