發(fā)布時間：2019-04-26 01:05

【摘要】：機體內(nèi)的次氯酸(HClO)是由過氧化氫和氯離子在髓過氧化物酶(MPO)催化作用下產(chǎn)生。由于其在細胞的分化、遷移、傳導(dǎo)和免疫等生理過程中起著非常重要的調(diào)控作用,因此對次氯酸的識別與檢測有著非常重要的意義。熒光探針法具有靈敏度高、選擇性好、檢測限低、響應(yīng)時間短、可視化檢測和原位無損等優(yōu)點,引起了科研工作者利用該方法對機體內(nèi)次氯酸的研究興趣。本文基于熒光探針與次氯酸的識別機制,主要綜述了近三年用來識別次氯酸熒光探針研究進展。討論了次氯酸熒光探針的設(shè)計策略、響應(yīng)模式以及生物應(yīng)用,并對次氯酸熒光探針的發(fā)展方向以及生物應(yīng)用進行了展望。
[Abstract]:Hypochlorite (HClO) is produced by hydrogen peroxide and chloride ion under the catalysis of myeloperoxidase (MPO). It plays an important role in the regulation of cell differentiation, migration, transmission and immunity, so it is of great significance for the recognition and detection of hypochlorite. The fluorescence probe method has the advantages of high sensitivity, good selectivity, low detection limit, short response time, visual detection and in-situ non-destructive, which has attracted researchers' interest in the study of hypochlorite in organism. Based on the recognition mechanism of fluorescence probe and hypochlorite, this paper mainly reviews the research progress of fluorescence probe for the recognition of hypochloric acid in recent three years. The design strategy, response mode and biological application of hypochlorite fluorescent probe were discussed. The development direction and biological application of hypochlorite fluorescent probe were also discussed.
【作者單位】： 大連理工大學(xué)精細化工國家重點實驗室;
【基金】：國家自然科學(xué)基金項目(No.21136002;21421005)資助~~
【分類號】：O657.3

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本文編號：2465618