【摘要】：生物離子通道能夠對環(huán)境刺激作出響應,有效地調節(jié)細胞內(nèi)外的物質平衡,保證體內(nèi)的正常生命活動.研究具有生物離子通道功能的人工離子通道對發(fā)展離子開關具有重要的意義.本工作利用電化學去合金法制備了具有三維通道結構的納米多孔金膜,并將其應用于離子通道,研究其離子輸運性質.在電場作用下,納米多孔金由于發(fā)生極化而使通道表現(xiàn)出離子整流性質.在納米多孔金表面修飾十二烷基硫醇單分子層,利用其疏水效應,通道能夠阻止離子的傳輸,使其處于"關閉"態(tài).溶液中的化學刺激如表面活性劑能夠增強電解質溶液在通道表面的浸潤,有利于離子的傳輸,使通道處于"打開"態(tài).這種單分子層修飾的納米多孔金表現(xiàn)出表面活性劑響應的離子開關特性.
[Abstract]:Biological ion channels can respond to environmental stimuli, effectively regulate the balance of substances inside and outside the cells, and ensure the normal life activities in the body. The study of artificial ion channel with biological ion channel is of great significance to the development of ion switch. In this work, nano-porous gold films with three-dimensional channel structure were prepared by electrochemical dealloying method, and applied to ion channels to study their ion transport properties. Under the action of electric field, nano-porous gold exhibits ionic rectifying properties due to polarization. The monolayer of dodecyl mercaptan modified on the surface of nano-porous gold can be "closed" because of its hydrophobic effect. The chemical stimulation in the solution such as surfactant can enhance the infiltration of electrolyte solution on the surface of the channel, which is favorable to the transport of ions and makes the channel "open". The monolayer modified nano-porous gold exhibits the ionic switching characteristics of surfactant response.
【作者單位】： 北京航空航天大學化學學院;
【基金】：國家自然科學基金(No.21571011) 國家重點基礎研究發(fā)展計劃(No.2014CB931803)資助~~
【分類號】：O614.123;TB383.1

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