【摘要】：本文運用脈沖輻解探究了不同自由基與藥物氟西汀(FLX)之間的反應。羥基自由基(?OH)與FLX反應生成苯環(huán)上的羥基加成物,而硫酸根陰離子自由基(SO_4?~-)則通過單電子氧化FLX生成苯陽離子自由基,該中間產(chǎn)物再進一步與水反應生成苯環(huán)上的羥基加成物。本研究測定了三種自由基?OH,水合電子(e_(aq)~-)以及SO_4?~-與FLX反應的反應速率常數(shù)分別為:7.8×10~9,2.3×10~9和1.1×10~9mol?L~(-1)?s~(-1)。本文還運用電子束輻照技術探究了不同輻照條件下的FLX降解效果,結合HPLC和紫外可見光譜儀進行分析。在N_2O和空氣飽和的兩種條件下,FLX溶液經(jīng)1.5 k Gy輻照后降解效率均達到90%以上,而N_2飽和條件下,加入0.1 mol?L~(-1)的叔丁醇的FLX溶液經(jīng)1.5 k Gy輻照后僅有43%分解。此外,酸性和中性條件下FLX的降解效率均大于堿性條件下的。結果闡明了飽和空氣的FLX溶液在中性條件下的降解效果最佳,且?OH誘導的反應比SO_4?~-更有利于FLX的分解。本研究期望對于進一步探究FLX的降解反應提供有益的幫助。
[Abstract]:The reaction between different free radicals and fluoxetine (FLX) was studied by pulse radiolysis. Hydroxyl radical (? OH) reacts with FLX to form hydroxyl adduct on benzene ring, while sulfate anion radical (SO_4?~-) produces benzene cationic radical by single electron oxidation of FLX. The intermediate product further reacts with water to form hydroxyl adducts on benzene ring. In this study, the reaction rate constants of three kinds of free radicals, OH, hydrated electrons (e-) and SO_4?~- and FLX, were determined as 7.8 脳 10 ~ (9) C ~ (2.3 脳 10 ~ (-1) and 1.1 脳 10 ~ (9) mol / L ~ (-1)? s ~ (-1), respectively. The degradation effect of FLX under different irradiation conditions was investigated by electron beam irradiation technique. The results were analyzed by HPLC and UV-Vis spectrometer. The degradation efficiency of FLX solution was more than 90% after 1.5 k Gy irradiation under the condition of N _ 2O and air saturation, while that of N _ 2 saturated was more than 90%. The FLX solution with 0.1 mol?L~ (-1) tert butanol was irradiated with 1.5 k Gy and only 43% was decomposed. In addition, the degradation efficiency of FLX in acidic and neutral conditions was higher than that in alkaline condition. The results showed that the FLX solution in saturated air had the best degradation efficiency under neutral conditions, and that the reaction induced by OH was more favorable to the decomposition of FLX than that of SO_4?~-. This study is expected to be helpful to further explore the degradation reaction of FLX.
【作者單位】： 上海大學環(huán)境與化學工程學院;中國科學院上海應用物理研究所;中國科學院大學;
【基金】：supported by the National Natural Science Foundation of China(21173252,41430644,11675098)~~
【分類號】：X703;O644.2

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