補腎促排卵湯對卵泡未破裂黃素化綜合征治療作用的臨床研究
發(fā)布時間：2019-04-12 20:19
【摘要】：目的：本研究通過觀察補腎促排卵湯對卵泡未破裂黃素化綜合征(luteinized unruptured follicle syndrome, LUFS)所致不孕癥患者促排卵周期的臨床療效,研討其作用機制,為中西醫(yī)結(jié)合最優(yōu)化防治LUFS和有效提高臨床妊娠率提供依據(jù)。方法：將納入的45例LUFS患者隨機分為三組,每組15例,藥物干預(yù)連續(xù)三個月經(jīng)周期,A組：補腎促排卵湯+人絨毛膜促性腺激素(humane chorionic gonadotropine, HCG),B組：血府逐瘀口服液+HCG, C組：單純HCG。比較三組排卵率、LUF周期復(fù)發(fā)率、臨床妊娠率等,研討補腎促排卵湯對該病的治療機制以及其與血府逐瘀口服液在協(xié)助排卵作用上的異同。同時,觀察既往促排卵治療史及原發(fā)疾病對LUFS復(fù)發(fā)的影響。結(jié)果：①三組排卵率分別為：A組70.7%,B組75%,C組47.5%；三組LUF周期復(fù)發(fā)率分別為：A組29.3%,B組25%,C組52.5%。三組排卵率、LUF周期復(fù)發(fā)率均有顯著性差異(P0.05)。②三組臨床妊娠率分別為：A組33.3%,B組6.7%,C組13.3%,差異不顯著(P0.05)。③三組促排卵治療總有效率分別為：A組86.7%,B組80%,C組66.7%,總療效差異不顯著(P0.05)。④既往有促排卵治療史患者LUF周期復(fù)發(fā)率較無者高,但差異不顯著(P0.05)。⑤原發(fā)病為子宮內(nèi)膜異位癥(endometriosis, EMS)患者較原發(fā)病為多囊卵巢綜合征(polycystic ovary syndrome, PCOS)、無或其他者更易發(fā)生LUFS,差異顯著(P0.01)。結(jié)論：①補腎促排卵湯、血府逐瘀口服液分別聯(lián)合HCG在LUFS所致不孕癥患者促排卵周期中運用均可顯著提高排卵率,效果均優(yōu)于單純使用HCG；②補腎促排卵湯也許對提高LUFS所致不孕癥患者的臨床妊娠率更有益；③行氣活血法可有效幫助排卵,加以補腎可能更有助于妊娠；④對于LUFS所致不孕癥患中原發(fā)病為EMS者,可于促排卵前改善原發(fā)病病癥,同時在促排卵周期及早采取治療措施,有效防止LUFS以“治未病”。
[Abstract]:Objective: to observe the clinical effect of Bushen inducing ovulation decoction on infertility induced by unruptured follicular luteinization syndrome (luteinized unruptured follicle syndrome, LUFS), and to explore its mechanism. It provides the basis for the optimal prevention and treatment of LUFS and the effective improvement of clinical pregnancy rate with integrated traditional Chinese and western medicine. Methods: forty-five patients with LUFS were randomly divided into three groups, each group (15 cases). The drug intervention lasted for three consecutive menstrual cycles. Group A: (humane chorionic gonadotropine, HCG), B group with Bushen inducing ovulation decoction human chorionic gonadotropin (humane chorionic gonadotropine, HCG), B) group: Xuefu Zhuyu oral liquid HCG, group. Group C: simple HCG. The ovulation rate, LUF cycle recurrence rate and clinical pregnancy rate were compared among the three groups. The therapeutic mechanism of Bushen Zhuyu decoction and Xuefu Zhuyu Oral liquid in assisting ovulation were discussed. At the same time, the history of ovulation induction therapy and the effect of primary diseases on the recurrence of LUFS were observed. Results: 1the ovulation rates of the three groups were 70.7% in Group A, 75% in Group B, 47.5% in Group C, and 29.3% in Group A, 25% in Group B and 52.5% in Group C. the recurrence rates of LUF in Group A, Group B and Group C were 29.3%, 25% and 52.5%, respectively. There was significant difference in ovulation rate and LUF cycle recurrence rate among the three groups (P0.05). 2 the clinical pregnancy rates of the three groups were 33. 3% in group A, 6. 7% in group B, 13. 3% in group C, respectively. The total effective rates of the three groups were 86.7% in group A, 80% in group B, 66.7% in group C, respectively. There was no significant difference in total curative effect (P0.05) .4The recurrence rate of LUF cycle in patients with previous history of ovulation induction therapy was higher than that in non-patients, but there was no significant difference (P0.05). 5 the primary onset of endometriosis (endometriosis,) was not significant (P0.05). Patients with EMS were more likely to develop LUFS, than patients with primary polycystic ovary syndrome without or without (polycystic ovary syndrome, PCOS), (P0.01). Conclusion: 1 Bushen ovulation inducing decoction and Xuefu Zhuyu Oral liquid combined with HCG in the ovulatory induction cycle of LUFS patients can significantly improve ovulation rate, and the effect is better than that of HCG; alone. (2) Bushen ovulation inducing decoction may be more beneficial to improve the clinical pregnancy rate of LUFS-induced infertility patients, 3) Qi-activating and blood-activating method can effectively help ovulation, and tonifying the kidney may be more helpful to pregnancy; (4) if the infertility caused by LUFS is EMS, the primary disease can be improved before ovulation induction, and the treatment measures should be taken as early as possible in the ovulation induction cycle to effectively prevent LUFS from being "treated without disease".
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R271.9
[Abstract]:Objective: to observe the clinical effect of Bushen inducing ovulation decoction on infertility induced by unruptured follicular luteinization syndrome (luteinized unruptured follicle syndrome, LUFS), and to explore its mechanism. It provides the basis for the optimal prevention and treatment of LUFS and the effective improvement of clinical pregnancy rate with integrated traditional Chinese and western medicine. Methods: forty-five patients with LUFS were randomly divided into three groups, each group (15 cases). The drug intervention lasted for three consecutive menstrual cycles. Group A: (humane chorionic gonadotropine, HCG), B group with Bushen inducing ovulation decoction human chorionic gonadotropin (humane chorionic gonadotropine, HCG), B) group: Xuefu Zhuyu oral liquid HCG, group. Group C: simple HCG. The ovulation rate, LUF cycle recurrence rate and clinical pregnancy rate were compared among the three groups. The therapeutic mechanism of Bushen Zhuyu decoction and Xuefu Zhuyu Oral liquid in assisting ovulation were discussed. At the same time, the history of ovulation induction therapy and the effect of primary diseases on the recurrence of LUFS were observed. Results: 1the ovulation rates of the three groups were 70.7% in Group A, 75% in Group B, 47.5% in Group C, and 29.3% in Group A, 25% in Group B and 52.5% in Group C. the recurrence rates of LUF in Group A, Group B and Group C were 29.3%, 25% and 52.5%, respectively. There was significant difference in ovulation rate and LUF cycle recurrence rate among the three groups (P0.05). 2 the clinical pregnancy rates of the three groups were 33. 3% in group A, 6. 7% in group B, 13. 3% in group C, respectively. The total effective rates of the three groups were 86.7% in group A, 80% in group B, 66.7% in group C, respectively. There was no significant difference in total curative effect (P0.05) .4The recurrence rate of LUF cycle in patients with previous history of ovulation induction therapy was higher than that in non-patients, but there was no significant difference (P0.05). 5 the primary onset of endometriosis (endometriosis,) was not significant (P0.05). Patients with EMS were more likely to develop LUFS, than patients with primary polycystic ovary syndrome without or without (polycystic ovary syndrome, PCOS), (P0.01). Conclusion: 1 Bushen ovulation inducing decoction and Xuefu Zhuyu Oral liquid combined with HCG in the ovulatory induction cycle of LUFS patients can significantly improve ovulation rate, and the effect is better than that of HCG; alone. (2) Bushen ovulation inducing decoction may be more beneficial to improve the clinical pregnancy rate of LUFS-induced infertility patients, 3) Qi-activating and blood-activating method can effectively help ovulation, and tonifying the kidney may be more helpful to pregnancy; (4) if the infertility caused by LUFS is EMS, the primary disease can be improved before ovulation induction, and the treatment measures should be taken as early as possible in the ovulation induction cycle to effectively prevent LUFS from being "treated without disease".
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R271.9
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