夏枯草開音合劑治療慢喉喑藥效學(xué)研究
[Abstract]:Objective to establish a rat model of chronic laryngeal aphasia induced by blood stasis and phlegm coagulation and to study the therapeutic effect of Prunella vulgaris Kaiyin mixture on chronic laryngeal aphasia in rats. Methods 50 SD rats of SPF grade were randomly divided into blank control group, (A), model control group, (B), low concentration group, (C), medium concentration group, (D), high concentration group, (E), After successful modeling of rats with slow larynx with blood stasis and phlegm coagulation, normal saline was used in group A and normal saline was used in group C and group C E was treated with low, medium and high concentration of Prunella vulgaris Kaiyin mixture respectively. After 30 days of gastric perfusion, the pathological changes of vocal cords were observed and analyzed statistically. Results the results of vocal cord test showed that the model was successful. After 30 days of gastric perfusion, the curative effect of Prunella vulgaris Kaiyin mixture on vocal cord hyperemia, edema, inflammatory cell infiltration and tissue proliferation was significantly different, and in the range of low, medium and high drug concentration, the curative effect increased with the increase of drug concentration. Conclusion Prunella vulgaris Kaiyin mixture has a significant therapeutic effect on chronic laryngeal aphasia of rats with blood stasis and phlegm coagulation.
【作者單位】: 上海中醫(yī)藥大學(xué)附屬市中醫(yī)醫(yī)院耳鼻咽喉科;
【基金】:上海市博士點(diǎn)基金項(xiàng)目(JX007301)
【分類號(hào)】:R276.1
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