【摘要】：目的:運用關聯(lián)規(guī)則方法分析中醫(yī)治療腦出血方劑,挖掘所選用的主要藥物及其用藥規(guī)律,為臨床治療腦出血提供參考。方法:搜集2005年-2015年符合納入標準的文獻中用中藥治療腦出血的方劑,選用內治方劑作為數(shù)據(jù)集,運用SPSS Clementine 12.0數(shù)據(jù)挖掘軟件對其藥物進行關聯(lián)規(guī)則分析,選用關聯(lián)規(guī)則Apriori算法建立數(shù)據(jù)挖掘模型,最小支持度為10%,最小置信度為70%,并對藥物配伍組合運用Web節(jié)點進行展示。結果:符合標準的治療腦出血方劑共157首,所用藥物共152味,總頻數(shù)1575次,使用頻數(shù)在10次以上的藥物共45味,共使用1290次,占腦出血藥物使用總頻數(shù)的81.90%。其中活血化瘀藥應用頻數(shù)最高,為373次,占總頻數(shù)的23.68%,其后依次為:清熱藥、平肝息風藥、補虛藥、化痰藥、瀉下藥、止血藥、開竅藥、利水滲濕藥、理氣藥、解表藥、安神藥、祛風濕藥、化濕藥、收澀藥、溫里藥、消食藥。共得到符合條件的藥物關聯(lián)規(guī)則376條,其中包含桃仁的規(guī)則最多,為217條。結論:活血化瘀藥為治療腦出血的主要藥物,常相須為用,或與平肝息風藥、補虛藥、清熱藥配伍使用。桃仁為治療腦出血第一要藥。通過關聯(lián)規(guī)則分析,可以挖掘出方劑數(shù)據(jù)庫中隱藏的藥物配伍規(guī)律,為臨床用藥提供方法和參考。
[Abstract]:Objective: to analyze the prescription of traditional Chinese medicine (TCM) for intracerebral hemorrhage by using association rule method, and to find out the main drugs used and their application rules, so as to provide reference for clinical treatment of intracerebral hemorrhage. Methods: the prescriptions for intracerebral hemorrhage were collected from 2005 to 2015, and the drug association rules were analyzed by SPSS Clementine 12.0 data mining software. The association rule Apriori algorithm is used to establish the data mining model. The minimum support is 10 and the minimum confidence is 70. The combination of drugs is displayed with Web node. Results: there were 157 prescriptions to treat intracerebral hemorrhage, 152 kinds of drugs were used, the total frequency was 1575 times, and 45 kinds of drugs were used more than 10 times, totally 1290 times, accounting for 81.90% of the total frequency of drug use in intracerebral hemorrhage. Among them, the application frequency of drugs for promoting blood circulation and removing stasis is the highest, 373 times, accounting for 23.68 times of the total frequency, followed by: heat-clearing medicine, medicine for calming the liver and relieving wind, medicine for tonifying deficiency, medicine for resolving phlegm, medicine for diarrhea, medicine for hemostasis, medicine for resuscitation, medicine for promoting water and infiltrating dampness, medicine for regulating qi, Antipods, antipsychotics, antirheumatic drugs, dehumidification drugs, astringent drugs, warm medicine, antiseptic drugs. A total of 376 eligible drug association rules were obtained, including 217 rules containing peach kernel. Conclusion: the drugs of activating blood circulation and removing blood stasis are the main drugs for treating cerebral hemorrhage, which should be used in combination with the drugs of calming the liver and relieving the wind, tonifying the deficiency and clearing the heat. Peach kernel is the first medicine to treat cerebral hemorrhage. By analyzing association rules, we can find out the hidden law of drug compatibility in prescription database, and provide methods and references for clinical use of drugs.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R277.7

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