【摘要】：目的：觀察解郁湯治療肝氣郁結(jié)型心血管神經(jīng)癥(Cardiovascular Neurosis, CN)的臨床療效及安全性,為中醫(yī)臨床治療心血管神經(jīng)癥提供新的治療思路和方法。方法：選取2015年5月至2016年1月在徐州市中醫(yī)院就診的肝氣郁結(jié)型心血管神經(jīng)癥住院患者60例。將患者進(jìn)行隨機(jī)分組,對照組28例,采用常規(guī)治療方法：鹽酸舍曲林、勞拉西泮片,合并心理干預(yù)。治療組加服解郁湯。15天為一個(gè)療程,共服用2個(gè)療程,觀察結(jié)束后,比較兩組治療前后漢密爾頓量表、中醫(yī)證候積分量表、生活質(zhì)量評定量表(SF-36)和安全性指標(biāo)的改變。運(yùn)用SPSS 19.0統(tǒng)計(jì)軟件進(jìn)行結(jié)果分析。結(jié)果：治療后兩組中醫(yī)證候積分量表、HAMA、HAMD量表評分均有明顯降低,治療組與對照組相比較,積分降低更為顯著(P0.05),差異有統(tǒng)計(jì)學(xué)意義,且治療組總有效率高于對照組,存在統(tǒng)計(jì)學(xué)差異(P0.05),提示解郁湯治療CN的臨床療效更為顯著,治療后兩組患者的生活質(zhì)量自評量表的評分均明顯升高。但治療組在改善患者參與社會(huì)活動(dòng)的能力、進(jìn)行正常的工作、改善心理健康方面療效更為顯著。結(jié)論：解郁湯聯(lián)合西藥及心理療法可以顯著改善肝氣郁結(jié)型心血管神經(jīng)癥患者的臨床癥狀,改善預(yù)后,無不良反應(yīng),安全性相對較好,值得臨床推廣及應(yīng)用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Jieyu decoction (JYD) in the treatment of cardiovascular neurosis of stagnation of liver-qi type (Cardiovascular Neurosis, CN), and to provide a new method for the treatment of cardiovascular neurosis in traditional Chinese medicine (TCM). Methods: from May 2015 to January 2016, 60 inpatients with liver qi depression cardiovascular neurosis were selected from Xuzhou Hospital of traditional Chinese Medicine. The patients were randomly divided into control group (n = 28) and control group (n = 28). The routine treatment methods were sertraline hydrochloride, lorazepam tablets and psychological intervention. The treatment group was treated with Jieyu decoction. 15 days was a course of treatment, and two courses of treatment were taken. After observation, the Hamilton scale and TCM syndrome integral scale before and after treatment were compared between the two groups. Changes of quality of life rating scale (SF-36) and safety index. The results were analyzed by SPSS 19.0 software. Results: after treatment, the scores of TCM syndrome integral scale and HAMA,HAMD scale in the two groups were significantly decreased, and the scores in the treatment group were significantly lower than those in the control group (P0.05), the difference was statistically significant. The total effective rate of the treatment group was higher than that of the control group, there was statistical difference (P0.05), suggesting that the clinical efficacy of Jieyu decoction in the treatment of CN was more significant, and the quality of life scale scores of the two groups were significantly increased after treatment. But the treatment group is more effective in improving patients' ability to participate in social activities, performing normal work and improving mental health. Conclusion: Jieyu decoction combined with western medicine and psychotherapy can significantly improve the clinical symptoms and prognosis of patients with liver qi depression cardiovascular neurosis.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R277.7

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