【摘要】：目的探討血府逐瘀湯治療對(duì)老年心肌梗死患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平的影響。方法老年心肌梗死患者100例,依據(jù)隨機(jī)數(shù)表法分為湯藥組和常規(guī)組,每組50例,常規(guī)組給予常規(guī)吸氧、抗凝抗血小板、調(diào)脂、降壓等基礎(chǔ)治療和150萬(wàn)U尿激酶溶栓治療,湯藥組在此基礎(chǔ)上給予血府逐瘀湯治療,采用酶聯(lián)免疫吸附法(ELISA)檢測(cè)血清SOD、MDA、NO水平,隨訪1年,分析所有患者治療有效、出血、治療前后左心室射血分?jǐn)?shù)(LVEF)和血清SOD、MDA、NO水平及治療后3、6、9、12個(gè)月的不良心血管事件發(fā)生情況。結(jié)果湯藥組治療后LVEF水平、治療有效率明顯高于常規(guī)組(P0.05),但二者出血率基本相同,無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);湯藥組治療后血清SOD、NO水平明顯高于常規(guī)組,MDA水平明顯低于常規(guī)組(P0.05);湯藥組治療后3、6、9、12個(gè)月的不良心血管事件發(fā)生率明顯低于常規(guī)組(P0.05)。結(jié)論血府逐瘀湯治療可有效提高老年心肌梗死患者的治療療效和心功能,有效改善患者的氧化應(yīng)激狀態(tài),且無(wú)增加患者出血風(fēng)險(xiǎn),有利于減少不良心血管事件的發(fā)生。
[Abstract]:Objective to investigate the effect of Xuefu Zhuyu decoction (XZD) on serum superoxide dismutase (SOD),) malondialdehyde (MDA),) nitric oxide (MDA),) (NO) levels in elderly patients with myocardial infarction. Methods 100 elderly patients with myocardial infarction were randomly divided into two groups (50 cases in each group). The patients in the routine group were treated with routine oxygen inhalation, anticoagulant and antiplatelet therapy, lipid regulation, hypotension and 1.5 million U urokinase thrombolytic therapy. On this basis, the decoction group was treated with Xuefu Zhuyu decoction, and the serum SOD,MDA,NO level was detected by Elisa (ELISA), followed up for 1 year. The levels of left ventricular ejection fraction (LVEF) and serum SOD,MDA,NO before and after treatment, and the occurrence of adverse cardiovascular events at 9 and 12 months after treatment. Results the level of LVEF and the effective rate after treatment in the decoction group were significantly higher than those in the routine group (P0.05), but the bleeding rate was basically the same between the two groups (P0.05). After treatment, the serum SOD,NO level in the decoction group was significantly higher than that in the routine group, and the level of MDA was significantly lower than that in the routine group (P0.05), and the incidence of adverse cardiovascular events in the decoction group was significantly lower than that in the routine group (P0.05). Conclusion Xuefu Zhuyu decoction can effectively improve the curative effect and cardiac function of the elderly patients with myocardial infarction, improve the oxidative stress state of the patients, and not increase the bleeding risk of the patients, which is helpful to reduce the occurrence of adverse cardiovascular events.
【作者單位】： 海南省中醫(yī)院心內(nèi)科;海南醫(yī)學(xué)院第一附屬醫(yī)院中醫(yī)科;
【基金】：2017年海南省自然科學(xué)基金項(xiàng)目(No.0112722212)
【分類號(hào)】：R259
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本文編號(hào)：2349290