【摘要】：目的：基于劉喜明教授治療2型糖尿病(Type 2 diabetes mellitus, T2DM) 586例病例資料,總結(jié)劉喜明教授治療T2DM及其并發(fā)癥的用藥規(guī)律。方法:1.收集2014年1月1日至2014年12月31日之間中國(guó)中醫(yī)科學(xué)院廣安門醫(yī)院劉喜明教授門診符合納入標(biāo)準(zhǔn)的T2DM病例;2.運(yùn)用Epidata3.1軟件,建立電子數(shù)據(jù)庫(kù),應(yīng)用SPSS 16.0軟件對(duì)相關(guān)資料進(jìn)行描述性統(tǒng)計(jì)分析,通過關(guān)聯(lián)規(guī)則挖掘藥物之間的相關(guān)性。結(jié)果：1.一般情況：男295例,女291例,男女比例為1.01:1；平均年齡54.44±8.12歲,年齡分布主要集中41～70歲之間；平均病程為8.83±2.09年,31.06%合并高血壓,21.84%合并血脂異；16.72%并發(fā)周圍神經(jīng)病變,10.07%并發(fā)糖尿病腎病,8.53%并發(fā)糖尿病視網(wǎng)膜病變。2.處方藥味劑量特點(diǎn)：每張?zhí)幏狡骄幬?.64±1.21味,平均劑量126.34±24.19g。3.T2DM用藥頻率分析：以清熱化痰、活血通絡(luò)等藥物為主,使用頻率前9味藥物依次是丹參、麥冬、姜半夏、黃連、炒枳實(shí)、地龍、川牛膝、蒲公英、土鱉蟲。4.糖尿病周圍神經(jīng)病變用藥頻率分析：以活血藥與通絡(luò)藥為主,使用頻率前9味依次為地龍、土鱉蟲、姜半夏、丹參、川牛膝、桑枝、橘絡(luò)、麥冬、片姜黃。5.糖尿病腎病用藥頻率分析：以益氣藥、養(yǎng)陰藥、活血藥為主,使用頻率前9味藥依次為丹參、生黃芪、麥冬、玉竹、穿山龍、川牛膝、土鱉蟲、地龍、北沙參。6.糖尿病視網(wǎng)膜病變用藥頻率分析：以養(yǎng)陰藥、清熱藥、活血藥為主,使用頻率前9味依次為丹參、麥冬、菊花、黃連、地龍、女貞子、白芍、蒲公英、山藥。7.常用藥物分類：常用藥有清熱藥、化痰藥、通絡(luò)藥、養(yǎng)陰藥、活血藥、補(bǔ)氣藥六大類。8.常用藥物配伍相關(guān)性分析：常見配伍有清熱藥與化痰藥、益氣藥與養(yǎng)陰藥、活血藥與通絡(luò)藥、活血藥與養(yǎng)陰藥。黃芪與麥冬、玉竹、北沙參配伍,置信度分別52.7%、36.5%、30.0%；黃連常與姜半夏、炒枳實(shí)、全瓜蔞、僵蠶、竹茹配伍,置信度分別為52.40%、49.40%、34.30%、22.70%、21.90%;丹參常與土鱉蟲、地龍配伍,置信度分別為21.4%、21.1%。結(jié)論:1.T2DM男女發(fā)病率相當(dāng),男女之比為1.01:1；平均年齡54.44±8.12歲,41～70歲最多；平均病程為8.83±2.09年。2.處方特點(diǎn)：每張?zhí)幏狡骄幬?.64±1.21味,平均劑量126.34±24.19g。處方藥味少,劑量輕。3.586例T2DM用藥以清熱化痰、活血通絡(luò)等藥物為主。4.糖尿病周圍神經(jīng)病變用藥以活血通絡(luò)藥為主。5.糖尿病腎病用藥以益氣養(yǎng)陰及活血藥為主6.糖尿病視網(wǎng)膜病變用藥以養(yǎng)陰清熱藥及活血藥為主。
[Abstract]:OBJECTIVE: Based on the data of 586 cases of type 2 diabetes mellitus (T2DM) treated by Professor Liu Ximing, the medication regularity of Professor Liu Ximing in treating T2DM and its complications was summarized. DM cases; 2. Using Epidata 3.1 software to establish an electronic database, using SPSS 16.0 software for descriptive statistical analysis of the relevant data, mining the correlation between drugs through association rules. Results: 1. General situation: 295 men, 291 women, the ratio of men and women is 1.01:1; the average age 54.44 (+ 8.12) years old, age distribution mainly concentrated 41-70 years. The average course of disease was 8.83+2.09 years, 31.06% with hypertension, 21.84% with dyslipidemia, 16.72% with peripheral neuropathy, 10.07% with diabetic nephropathy and 8.53% with diabetic retinopathy. Analysis: the main drugs used for clearing away heat and reducing phlegm, activating blood circulation and dredging collaterals were 9 Salvia miltiorrhiza, Radix Ophiopogon, Rhizoma Pinelliae, Rhizoma Coptidis, fry Fructus aurantii Immaturus, earthworm, Achyranthes bidentata, Taraxacum mongolicum, woodlouse worm.4., drug frequency of diabetic peripheral neuropathy: blood activating drugs and dredging collaterals. The first 9 flavors were earthworm, woodlouse worm, Jiang Banxia. Radix salviae miltiorrhizae, Radix Achyranthis bidentata, Ramulus Mori, orange peel, Ophiopogon japonicus, turmeric.5., and diabetic nephropathy: analysis of the frequency of medication for diabetes nephropathy: the main drugs are Qi supplementing, Yin nourishing and blood activating drugs. The frequency of the first 9 drugs is Salvia miltiorrhiza, Radix Astragali, Radix Ophiopogon, polygonatum odoratum, Dioscorea nipponica, Achyranthes bidentata, woodlouse worm, earthworm, Radix gophi.6., and diabetic retinopathy. Thermal drugs, blood-activating drugs mainly, the first nine use frequency in turn is Salvia miltiorrhiza, Ophiopogon japonicus, Chrysanthemum, Coptis chinensis, earthworm, Ligustrum lucidum, Paeonia lactiflorum, dandelion, yam. Supplementing qi and Yin nourishing drugs, activating blood circulation drugs and dredging collaterals, activating blood circulation drugs and nourishing Yin drugs, Astragalus membranaceus and Ophiopogon japonicus, polygonatum odoratum and Radix gophanae radix, the confidence level is 52.7%, 36.5%, 30% respectively; Huang Lianchang and Jiang Banxia, stir fried Fructus aurantii Immaturus, Fructus Trichosanthis, Bombyx silkworm and bamboo Ru are 52.40%, 49.40%, 34.30%, 22.70% and 21.90% respectively; the salvia miltiorrhiza is often compatible with woodlouse worm, earthworm, and confidence level. The incidence of T2DM was 21.4% and 21.1% respectively. The ratio of male to female was 1.01:1. The average age was 54.44 (+ 8.12) years, and the maximum was 41-70 years. The average course of disease was 8.83 (+ 2.09 years). The main drugs used in diabetic peripheral neuropathy are Huoxue Tongluo. 5. The main drugs used in diabetic nephropathy are Yiqi Yangyin and Huoxue. 6. The main drugs used in diabetic retinopathy are Yangyin Qingre and Huoxue.
【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R249;R259

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