本文選題：葶藶大棗瀉肺湯 + 真武湯��； 參考：《黑龍江省中醫(yī)藥科學(xué)院》2016年碩士論文

【摘要】：目的觀察葶藶大棗瀉肺湯合真武湯治療心腎陽虛型慢性心力衰竭的療效及安全性,旨在為臨床上治療心力衰竭提供實(shí)用而有價(jià)值的治療方案。方法根據(jù)納入標(biāo)準(zhǔn)與排除標(biāo)準(zhǔn),于黑龍江省中醫(yī)醫(yī)院心內(nèi)科門診患者中選取60例,采用隨機(jī)對照研究,將試驗(yàn)對象分為試驗(yàn)組與對照組。兩組患者的一般資料無統(tǒng)計(jì)學(xué)差異。對照組予芪藶強(qiáng)心膠囊治療,每日3次,一次8粒;試驗(yàn)組采用葶藶大棗瀉肺湯合真武湯治療,每日一劑,一日兩次,早晚餐后半小時(shí)溫服。28天后進(jìn)行臨床療效評定。系統(tǒng)觀察并比較治療前、后兩組患者之間及試驗(yàn)組組內(nèi)的中醫(yī)證候積分、血清C-反應(yīng)蛋白(CRP)、心功能分級、左室射血分?jǐn)?shù)(LVEF)、血清NT-proBNPN(端腦納肽前體)的檢測結(jié)果。密切觀察兩組患者治療前后肝腎功能以及血、尿、便常規(guī)的變化。結(jié)果經(jīng)過28天的治療,臨床研究表明在中醫(yī)證候療效方面試驗(yàn)組優(yōu)于對照組(P0.05),其中試驗(yàn)組舌象、脈象方面的改善情況明顯優(yōu)于對照組(P0.05);試驗(yàn)組左室射血分?jǐn)?shù)(LVEF)的增加幅度明顯優(yōu)于對照組(P0.05);兩組血檢CRP數(shù)值均降低,治療組較對照組降低更明顯(P0.05);試驗(yàn)組血清NT-proBNP(N端腦納肽前體)值的降低幅度明顯優(yōu)于對照組(P0.05)。試驗(yàn)組及對照組療前療后肝、腎功能、血、尿、便常規(guī)均無明顯變化(P0.05)?結(jié)論葶藶大棗瀉肺湯合真武湯能改善CHF患者的臨床癥狀和體征,提高患者生命質(zhì)量,并通過降低NT-proBNP及C反應(yīng)蛋白,增加LVEF等方面增強(qiáng)心臟功能,且具有良好的安全性、無不良反應(yīng)?
[Abstract]:Objective to observe the efficacy and safety of Tinglida Zao Xiefei decoction combined with Zhenwu decoction in the treatment of chronic heart failure with deficiency of heart and kidney yang in order to provide a practical and valuable therapeutic scheme for the treatment of heart failure. Methods according to the criteria of inclusion and exclusion, 60 outpatients in Department of Cardiology, Heilongjiang Province traditional Chinese Medicine Hospital, were selected and randomly controlled. The subjects were divided into two groups: the experimental group and the control group. There was no statistical difference in general data between the two groups. The control group was treated with Qiliqiangxin capsule, 3 times a day, 8 capsules once a day, and the experimental group was treated with Tinglida Zao Xiefei decoction and Zhenwu decoction, once a day, twice a day, and half an hour after the morning and evening meal. The scores of TCM syndromes, serum C-reactive protein (CRP), cardiac function grade, left ventricular ejection fraction (LVEF) and serum NT-proBNPN (terminal brain natriuretic peptide precursor) were observed and compared before and after treatment. Observe the changes of liver and kidney function, blood and urine before and after treatment. Results after 28 days of treatment, the clinical study showed that the experimental group was superior to the control group in the curative effect of TCM syndromes, and the tongue picture of the experimental group was better than that of the control group. The improvement of pulse was better than that of control group (P 0.05), the increase of left ventricular ejection fraction (LVEF) was better than that of control group (P 0.05). Compared with the control group, the serum NT-proBNPN N-terminal nalapeptide precursor in the treatment group was significantly lower than that in the control group (P 0.05), and the serum NT-proBNPN N-terminal nalapeptide precursor in the treatment group was significantly lower than that in the control group. There were no significant changes in liver, kidney function, blood, urine and stool routine after treatment in the experimental group and the control group before and after treatment. Conclusion Tinglida Zao Xiefei decoction combined with Zhenwu decoction can improve the clinical symptoms and signs of CHF patients, improve the quality of life of CHF patients, enhance heart function by reducing NT-proBNP and C-reactive protein, increase LVEF and so on, and have good safety. No adverse reactions?
【學(xué)位授予單位】：黑龍江省中醫(yī)藥科學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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