本文選題：參芪解毒膏 + 脾腎虛衰�。� 參考：《山東中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察參芪解毒膏作為溫陽(yáng)益氣、解毒瀉濁作用的復(fù)方對(duì)脾腎虛衰、濁毒潴留型慢性腎衰早中期的臨床治療效果,進(jìn)一步指導(dǎo)醫(yī)師在臨床中對(duì)于方藥的選擇與應(yīng)用。方法:將70例符合脾腎虛衰、濁毒潴留型慢性腎衰早中期的患者隨機(jī)分為治療組(35例)和對(duì)照組(35例),治療組在一般治療的基礎(chǔ)上加用參芪解毒膏;對(duì)照組在一般治療的基礎(chǔ)上加用尿毒清顆粒。觀察兩組患者治療前后的臨床癥狀積分及血肌酐、血尿酸、內(nèi)生肌酐清除率、血尿素氮、血紅蛋白、血白蛋白、總膽固醇、甘油三酯、24小時(shí)尿蛋白定量等實(shí)驗(yàn)室指標(biāo)的改善情況。結(jié)果:1.治療組治療后的總療效有效率為88.57%,優(yōu)于對(duì)照組的74.29%(P0.05);2.對(duì)倦怠乏力/氣短懶言、畏寒肢冷、食少納呆、腰部冷痛、腰膝酸軟、夜尿清長(zhǎng)、大便不實(shí)這幾組癥狀的療效,參芪組較尿毒清組有顯著優(yōu)勢(shì)(P0.01);3.治療后兩組均可降低BUN、Scr、Ccr、UA、CO2CP、TC、TG、UTP水平,提高Hb、ALb水平,參芪組在降低UTP,提高ALb方面優(yōu)于對(duì)照組(P0.05)。結(jié)論:參芪解毒膏可以有效地減少尿微量白蛋白,降低BUN、Scr、Ccr、UA、CO2CP、TC、TG、UTP的水平,同時(shí)亦可提高Hb、ALb水平,改善腎臟功能,延緩慢性腎衰的進(jìn)程,為治療脾腎虛衰、濁毒潴留型慢性腎衰提供了新的有效途徑。
[Abstract]:Objective: to observe the clinical therapeutic effect of Shenqi jiedu ointment (SJO) on chronic renal failure with deficiency of spleen and kidney and retention of turbid poison in early and middle period, and to guide doctors to choose and apply prescriptions in clinic. Methods: 70 cases of chronic renal failure with deficiency of spleen and kidney and retention of turbid toxin were randomly divided into treatment group (n = 35) and control group (n = 35). The treatment group was treated with Shenqi jiedu ointment on the basis of general treatment. The control group was treated with Niaoduqing granules on the basis of general treatment. The clinical symptom scores, serum creatinine, serum uric acid, endogenous creatinine clearance rate, blood urea nitrogen, hemoglobin, serum albumin, total cholesterol were observed before and after treatment. Improvement of 24-hour urinary protein quantification and other laboratory indexes of triglyceride. The result is 1: 1. The total effective rate of the treatment group was 88.57, which was better than that of the control group (74.29%). The effects of fatigue / shortness of breath, cold limbs, low food intake, cold waist pain, sore waist knee, long night urine and untrue stool in Shenqi group were significantly higher than those in Niuduqing group (P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01). After treatment, both groups could decrease the level of UTP and increase the level of HbTG-ALB in both groups. Shenqi group was superior to the control group in terms of reducing UTP and increasing ALb (P 0.05). Conclusion: Shenqi jiedu ointment can effectively reduce urinary microalbuminuria, decrease the level of UTP of BUNG Scrr CcrC UAUACO 2CPN TGG, increase HB level, improve renal function, delay the process of chronic renal failure, in order to treat spleen and kidney deficiency failure. Chronic renal failure with turbid toxin retention provides a new effective approach.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R277.5

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