發(fā)布時(shí)間：2018-05-23 23:28

  本文選題：養(yǎng)血溫經(jīng) + 陰寒型�。� 參考：《華北理工大學(xué)》2016年碩士論文

【摘要】：目的通過觀察養(yǎng)血溫經(jīng)方對陰寒型雷諾氏病患者的臨床療效,客觀地評價(jià)自擬養(yǎng)血溫經(jīng)方治療陰寒型雷諾氏病的臨床療效及安全性,為治療本病找到新的思路方法,并及早推廣使用。方法收集自2014年7月至2016年2月期間就診患者,共計(jì)62例。所有研究對象年齡均在20~40歲,均符合中醫(yī)診斷標(biāo)準(zhǔn)、西醫(yī)診斷標(biāo)準(zhǔn)、納入標(biāo)準(zhǔn),且未在排除標(biāo)準(zhǔn)范圍內(nèi)。治療組病例32例,給予口服自擬養(yǎng)血溫經(jīng)方治療;對照組病例30例,給予口服復(fù)方夏天無片治療。4周為一個(gè)療程,2個(gè)療程后統(tǒng)計(jì)結(jié)果。對兩組總體的療效、單項(xiàng)癥狀積分、紅細(xì)胞變形指數(shù)、免疫系列及補(bǔ)體測定和握拳試驗(yàn)進(jìn)行有效統(tǒng)計(jì)并隨時(shí)記錄結(jié)果。同時(shí)對一般體檢項(xiàng)目做好登記,做出前后對比,對不良反應(yīng)等現(xiàn)象的發(fā)生及處理方法做好詳細(xì)記錄,為本實(shí)驗(yàn)的安全性評價(jià)做好充分詳細(xì)的準(zhǔn)備。一般體檢項(xiàng)目包括身高、體重、血、尿、便常規(guī)、肝腎功能、心電圖。對以上進(jìn)行綜合分析后評定其療效。結(jié)果1中醫(yī)綜合療效比較:治療組臨床痊愈率為9.37%,顯效率為53.12%,有效率為28.12%,總有效率為90.62%;對照組臨床痊愈率為3.33%,顯效率為23.33%,有效率為43.33%,總有效率為70%。2中醫(yī)單項(xiàng)癥狀積分比較:兩組積分較治療前均有所降低。治療組在“肢端顏色、冷感、腫脹感、麻木感、疼痛感”方面與對照組差異明顯,“舌象、脈象”癥狀差異不顯著。總體顯示治療組效果優(yōu)于對照組。3紅細(xì)胞變形指數(shù)比較:治療后結(jié)果顯示P=0.021,治療組比對照組差異明顯。4免疫系列及補(bǔ)體測定比較:用獨(dú)立樣本t檢驗(yàn)顯示,治療后兩組免疫系列及補(bǔ)體比較P0.05,差異明顯,有統(tǒng)計(jì)學(xué)意義,治療組效果優(yōu)于對照組。5握拳試驗(yàn)比較:治療后養(yǎng)血溫經(jīng)方組陽性反應(yīng)人數(shù)較復(fù)方夏天無片組明顯減少,對比效果明顯。6安全性比較:兩組一般體檢項(xiàng)目前后變化不顯著,在肝腎功能及血常規(guī)方面做出的具體數(shù)據(jù)統(tǒng)計(jì)分析后顯示,P值均0.05,兩組比較無統(tǒng)計(jì)學(xué)意義。7整體實(shí)驗(yàn)過程中未出現(xiàn)不良反應(yīng),用藥安全可靠。結(jié)論1自擬養(yǎng)血溫經(jīng)方可有效減輕陰寒型雷諾氏病患者的痛苦,使患者臨床癥狀減輕,控制發(fā)病率,值得在患者中推廣應(yīng)用。2自擬養(yǎng)血溫經(jīng)方這一中醫(yī)藥治療方法在臨床實(shí)驗(yàn)中,對肝腎功能及血常規(guī)指標(biāo)變化無影響,療效安全可靠。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Yangxue Wenjing recipe (YXWJF) in the treatment of Yin-cold Raynaud's disease by observing the clinical effect of YXWJD on the patients with Yin-cold type Raynaud's disease, and to find a new way of thinking for the treatment of this disease. And early promotion of use. Methods 62 patients were collected from July 2014 to February 2016. All the subjects were 20 ~ 40 years old, which were in accordance with the diagnostic criteria of traditional Chinese medicine and western medicine, and were not included in the exclusion criteria. 32 cases in the treatment group were treated with self-made decoction of nourishing blood and wenjing, while 30 cases in the control group were treated with compound summer without tablets for 4 weeks as a course of treatment, and statistical results were obtained after 2 courses of treatment. The total curative effect, single symptom score, erythrocyte deformability index, immune series, complement determination and fist grip test in both groups were counted and recorded at any time. At the same time, the general physical examination items are registered, compared before and after, and the occurrence and treatment of adverse reactions are recorded in detail, so as to prepare the safety evaluation of this experiment in detail. General physical examination items include height, weight, blood, urine, stool routine, liver and kidney function, electrocardiogram. The curative effect was evaluated after comprehensive analysis. Results 1Compared with the comprehensive curative effect of TCM, the clinical cure rate of the treatment group was 9.377.The effective rate was 53.12, the effective rate was 28.12and the total effective rate was 90.62.The clinical cure rate of the control group was 3.33, the markedly effective rate was 23.33, the effective rate was 43.33, and the total effective rate was 70.2 single symptoms of TCM. Integral comparison: both groups had lower scores than before treatment. There were significant differences between the treatment group and the control group in terms of "extremity color, cold feeling, swelling feeling, numbness feeling, pain feeling", but there was no significant difference in the symptoms of "tongue image and pulse image" between the treatment group and the control group. The effect of the treatment group was better than that of the control group (P 0.021). The difference of immune series and complement in the treatment group was significantly higher than that in the control group. After treatment, the immune series and complement were significantly different between the two groups (P0.05). The effect of the treatment group was better than that of the control group (P 0.05). After treatment, the number of positive reaction in the Yangxue Wenjing prescription group was significantly lower than that in the compound summer without tablet group. Safety comparison: there was no significant change before and after the general physical examination in the two groups. The statistical analysis of the specific data of liver and kidney function and blood routine showed that the P value was 0.05. There was no significant difference between the two groups. 7. There was no adverse reaction in the whole experiment, and the medication was safe and reliable. Conclusion (1) Yangxue Wenjing prescription can effectively alleviate the pain of the patients with Yin-cold Raynaud's disease, reduce the clinical symptoms and control the incidence of disease. It is worth popularizing and applying the traditional Chinese medicine treatment method of self-made nourishing blood and wenching meridian prescription in the clinical experiment, which has no effect on the changes of liver and kidney function and blood routine index, and the curative effect is safe and reliable.
【學(xué)位授予單位】：華北理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R277.7

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