發(fā)布時(shí)間：2018-05-08 17:04

  本文選題：原發(fā)性失眠 + 肝郁氣結(jié)證�。� 參考：《南京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：研究目的:收集肝郁氣結(jié)型失眠患者的臨床資料,采用自身前后對(duì)照的研究方法,初步探究自擬安神合劑對(duì)原發(fā)性失眠肝郁氣結(jié)證的臨床療效,為其臨床應(yīng)用提供指導(dǎo)。研究方法:采用自身前后對(duì)照的研究方法。從2016年3月-2017年2月于江蘇省中醫(yī)院腦病中心門(mén)診就診的失眠患者中,選取符合本試驗(yàn)納入標(biāo)準(zhǔn)的肝郁氣結(jié)型失眠患者,充分知情同意后予安神合劑治療。分別于治療前(第0天)、服藥后第14天及第28天評(píng)估其匹茲堡睡眠質(zhì)量指數(shù)量表、中醫(yī)證候分級(jí)量化評(píng)分、肝郁氣結(jié)證量化積分情況。采用SPSS21.0對(duì)所得資料進(jìn)行統(tǒng)計(jì)學(xué)分析,對(duì)比治療前后各療效指標(biāo)的差異性。結(jié)果:本研究共納入53例患者,失訪5例,最終只納入48例患者,經(jīng)統(tǒng)計(jì)分析后結(jié)果顯示:與治療前(第0日)相比,服藥第14天、28天后患者匹茲堡睡眠質(zhì)量指數(shù)、中醫(yī)證候分級(jí)量化評(píng)分、肝郁氣結(jié)證量化積分均有改善,其差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:本研究初步表明自擬安神合劑治療原發(fā)性失眠肝郁氣結(jié)證有較好的療效。但本研究存在一定的局限性,尚需進(jìn)一步的隨機(jī)、雙盲、大樣本、多中心研究證明其臨床療效,為其臨床應(yīng)用提供更可靠的依據(jù)。
[Abstract]:Objective: to collect the clinical data of insomnia with stagnation of liver-qi and to explore the clinical effect of Anshen mixture on the syndrome of primary insomnia with stagnation of liver-qi and to provide guidance for its clinical application. Methods: self-control method was used. From March 2016 to February 2017, patients with insomnia were selected from the clinic of Encephalopathy Center of Jiangsu Provincial traditional Chinese Medicine Hospital. The patients with liver depression and Qi knot type who met the criteria of this experiment were treated with Anshen mixture after fully informed consent. The Pittsburgh Sleep quality Index scale (Pittsburgh Sleep quality Index scale), the quantitative score of TCM syndrome grading, and the quantitative score of liver stagnation qi syndrome were evaluated before treatment (day 0, day 14 and day 28 after taking medicine). The data were statistically analyzed by SPSS21.0, and the difference of curative effect indexes before and after treatment was compared. Results: a total of 53 patients were included in this study, 5 patients were lost, and only 48 patients were included in the study. The results of statistical analysis showed that compared with before treatment (day 0), the Pittsburgh sleep quality index of patients after 14 days and 28 days of medication was higher than that before treatment. The classification and quantification score of TCM syndromes and the quantitative integral of liver-stagnation qi syndrome were all improved, and the difference was statistically significant (P 0.05). Conclusion: this study preliminarily indicated that the self-made Anshen mixture had better curative effect on primary insomnia. But there are some limitations in this study, which need to be further randomized, double-blind, large sample, multi-center study to prove its clinical efficacy, to provide a more reliable basis for its clinical application.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R256.23

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本文編號(hào)：1862258