本文選題：耳穴貼壓 + 原發(fā)性痛經(jīng)　； 參考：《湖南中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:通過(guò)研究耳穴貼壓對(duì)原發(fā)性痛經(jīng)患者前列腺素(PGF2α、PGE2、PGF2α/PGE2)、β-EP、血栓素(TXA2、TXB2)的影響,探討耳穴貼壓防治原發(fā)性痛經(jīng)的效應(yīng)機(jī)制,為推廣應(yīng)用耳穴貼壓防治原發(fā)性痛經(jīng)提供實(shí)驗(yàn)依據(jù)。方法:耳穴貼壓組隨機(jī)選入原發(fā)性痛經(jīng)患者18例,正常對(duì)照組隨機(jī)選入身體健康女大學(xué)生14例。耳穴取穴內(nèi)生殖器、內(nèi)分泌、交感、皮質(zhì)下、神門(mén)、肝、腎,每日按壓4次,每次間隔4小時(shí),每次每穴按壓20次,于第3日更換對(duì)側(cè)耳穴,連續(xù)治療3個(gè)月經(jīng)周期。均于治療前(納入實(shí)驗(yàn)后的第一個(gè)月經(jīng)周期)月經(jīng)來(lái)潮24h內(nèi)及治療后(治療組治療的第三個(gè)月經(jīng)周期)月經(jīng)來(lái)潮24h內(nèi)采集血液樣本。采用酶聯(lián)免疫法測(cè)定血清前列腺素(PGF2α、PGE2)、β-EP、血栓素(TXA2、TXB2)的含量。結(jié)果:1.耳穴貼壓組治療前PGF2α、PGE2含量和PGF2α/PGE2值均高于正常對(duì)照組水平(P0.05),治療后PGF2α、PGE2、PGF2α/PGE2值水平均有所下降(P0.05),PGF2α/PGE2值與正常對(duì)照組無(wú)差異(P0.05)。2.耳穴貼壓組β-EP含量在治療前與正常對(duì)照組相當(dāng),差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療后耳穴貼壓組β-EP含量明顯高于治療前(P0.01)和正常對(duì)照組(P0.01)。3.耳穴貼壓組治療前TXA2、TXB2均高于正常對(duì)照組(P0.01),治療后TXA2、TXB2水平明顯下降(P0.01),與正常對(duì)照組無(wú)差異(P0.05)。結(jié)論:耳穴貼壓防治原發(fā)性痛經(jīng)的效應(yīng)機(jī)制,可能與調(diào)節(jié)原發(fā)性痛經(jīng)患者前列腺素(PGF2α、PGE2、PGF2α/PGE2)、β-EP、血栓素(TXA2、TXB2)水平相關(guān)。
[Abstract]:Objective: to study the effect of auricular point plaster pressure on PGE2a / PGE2 偽 / PGE2 偽, 尾 -EPand TXA2TXB2 in patients with primary dysmenorrhea, and to explore the mechanism of auricular acupoint plaster pressure in the prevention and treatment of primary dysmenorrhea, so as to provide experimental basis for popularizing the treatment of primary dysmenorrhea by auricular plaster pressure. Methods: 18 cases of primary dysmenorrhea were randomly selected into auricular acupoint pressing group and 14 cases of healthy female college students were randomly selected into normal control group. The internal genitalia, endocrine, sympathetic, subcortical, Shenmen, liver, kidney, pressing 4 times daily, every time 4 hours, each point pressing 20 times, on the third day to replace the contralateral auricular points, continuous treatment for 3 menstrual cycles. Blood samples were collected within 24 hours of menorrhagia before treatment (the first menstrual cycle after the experiment) and within 24 hours after menorrhagia (the third menstrual cycle of treatment group). The levels of serum prostaglandin PGF2 偽, 尾 -EPand TXA2TXB2 were determined by enzyme-linked immunosorbent assay (Elisa). The result is 1: 1. The content of PGF2 偽 PGE2 and PGF2 偽 / PGE2 before treatment in auricular acupoint plaster group were higher than those in normal control group (P 0.05). After treatment, the levels of PGF2 偽 PGE2 偽 PGE2 偽 / PGE2 / PGE2 decreased, and there was no significant difference between the two groups in PGF2 偽 / PGE2 / PGE2 value compared with the normal control group (P0.05PGE2 / PGE2). The content of 尾 -EP in the auricular point plaster group was similar to that in the normal control group before treatment, and the difference was not statistically significant (P 0.05). After treatment, the 尾 -EP content in the auricular point pressing group was significantly higher than that in the auricular point pressing group before treatment (P 0.01) and in the normal control group (P 0.01). The levels of TXA _ 2 and TXB _ 2 in auricular acupoint plaster group were higher than those in normal control group before treatment (P 0.01). After treatment, the level of TXA _ 2 and TXB _ 2 decreased significantly (P _ (0.01)), but there was no difference between the two groups (P _ (0.05)). Conclusion: the mechanism of auricular plaster pressure in preventing and treating primary dysmenorrhea may be related to regulating the level of PGF 2 偽 / PGE 2 偽 / PGE 2 偽, 尾 -EPK, TXA 2 and TXB 2 in patients with primary dysmenorrhea.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R246.3

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 石巖;龐立健;劉創(chuàng);劉勇明;劉妍彤;王斯涵;呂曉東;;基于中醫(yī)外治法的原發(fā)性痛經(jīng)干預(yù)規(guī)律探究[J];世界科學(xué)技術(shù)-中醫(yī)藥現(xiàn)代化;2017年03期

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本文編號(hào)：1848950