本文選題：調(diào)更益經(jīng)湯 + 腎虛血瘀型　； 參考：《山東中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察調(diào)更益經(jīng)湯治療圍絕經(jīng)期婦女腎虛血瘀型骨質(zhì)疏松癥的臨床療效,以便于更好地尋找辦法解決其不適癥狀。方法:于青島市海慈醫(yī)療集團2014年3月至2015年6月中醫(yī)婦科門診和病房所篩選出64例診斷為本病的患者,然后把64例患者隨機分為了治療組和對照組。治療組服用導(dǎo)師徐慧軍教授自擬方調(diào)更益經(jīng)湯,對照組患者服用仙靈骨葆膠囊,治療2個療程。觀察兩組患者治療前后的臨床癥狀(腰膝酸軟、頸背疼痛、眩暈耳鳴、失眠多夢、健忘、經(jīng)少、經(jīng)閉)及血清堿性磷酸酶(ALP)、血清鈣、促卵泡生成素(FSH)、雌二醇(E2)以及骨密度(左側(cè)髖骨、第1-4腰椎正側(cè)位骨密度)的變化。結(jié)果:本次臨床研究結(jié)果表明:(1)治療組的總有效率可達83%,對照組的總有效率為63%,(P0.05),說明了調(diào)更益經(jīng)湯對治療本病更具有優(yōu)勢。(2)兩組患者的臨床癥狀總積分相對于以前均有所下降,治療組優(yōu)于對照組,尤其對于(腰膝酸軟、頸背疼痛)的主要癥狀方面。(3)在內(nèi)分泌方面,兩組在治療后的E2、FSH水平均有所改善,兩組在治療前后相比具有顯著性差異(p0.05);組間比較無明顯區(qū)別(p0.05)。表明在改善激素水平方面調(diào)更益經(jīng)湯具有更好的療效。(4)兩組治療后的骨密度均較治療前略有所上升,在腰椎骨密度方面治療前后比較有顯著性差異(p0.05),組間比較有顯著性差異(p0.05),治療組要優(yōu)于對照組。在髖骨骨密度方面治療前后比較有顯著性差異(P0.05),組間比較無顯著差異(p0.05),表明調(diào)更益經(jīng)湯在改善髖骨骨密度方面無明顯優(yōu)勢。結(jié)論:調(diào)更益經(jīng)湯對本病的治療較為顯著,能夠改善生殖內(nèi)分泌、提高骨密度、改善血清堿性磷酸酶(ALP)、血清鈣的水平以達到改善臨床癥狀的目的,但由于骨密度變化較慢,有待繼續(xù)觀察。
[Abstract]:Objective: to observe the clinical effect of Tiaogeng Yijing decoction in treating peri-menopausal women with kidney deficiency and blood stasis type osteoporosis in order to find a better solution to its unwell symptoms.Methods: from March 2014 to June 2015, 64 patients were selected from TCM gynecological outpatient department and ward of Qingdao Haici Medical Group, and 64 patients were randomly divided into treatment group and control group.The treatment group was treated with Professor Xu Huijun's own prescription Tiaogeng Yijing decoction and the control group was treated with Xianling Gubao capsule for 2 courses of treatment.To observe the clinical symptoms before and after treatment (waist and knee weakness, neck pain, vertigo tinnitus, insomnia and dream, amnesia, menstrual obstruction), serum alkaline phosphatase (ALP), serum calcium,Changes of follicle stimulating hormone (FSH), estradiol (E2) and bone mineral density (left hip, 1-4 lumbar vertebrae positive and lateral BMD).Results: the results of this clinical study show that the total effective rate of the treatment group can reach 833%, and the total effective rate of the control group is 63% (P 0.05), which indicates that Tiaogenyi Jing decoction has more advantages in the treatment of this disease.The treatment group was superior to the control group, especially for the main symptoms (waist and knee pain, neck pain) in endocrine, the two groups after the treatment of E2FSH levels improved,There was significant difference between the two groups before and after treatment (P 0.05), but there was no significant difference between the two groups (P 0.05).It indicated that Tiao Gengyi Jing decoction had better curative effect in improving hormone level.) the bone mineral density of both groups after treatment was slightly higher than that before treatment.There were significant differences in bone mineral density of lumbar vertebrae before and after treatment (P 0.05) and between groups (P 0.05). The treatment group was better than the control group.There was significant difference in bone mineral density of hip before and after treatment (P 0.05), but there was no significant difference between groups (P 0.05), which indicated that Tiaogeng Yijing decoction had no obvious advantage in improving bone mineral density of hip.Conclusion: Tiaogeng Yijing decoction can improve reproductive endocrine, bone mineral density, serum alkaline phosphatase and serum calcium to improve clinical symptoms, but the change of bone mineral density is slow.It remains to be seen.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R271.116

【參考文獻】

相關(guān)期刊論文 前10條

1 沈茂榮;馮彥江;王甜;王鵬云;周俠;;華佗五禽戲鍛煉對絕經(jīng)女性腰椎骨密度的影響[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2013年08期

2 盛彤;謝培鳳;王新祥;;原發(fā)性骨質(zhì)疏松癥從脾論治及相關(guān)機制探討[J];中華中醫(yī)藥雜志;2012年07期

3 唐作安;;補腎強骨活血方治療原發(fā)性骨質(zhì)疏松癥42例臨床觀察[J];中醫(yī)藥導(dǎo)報;2012年04期

4 杜新平;游俊;;絕經(jīng)前后諸癥宜從脾胃論治[J];江漢大學(xué)學(xué)報(自然科學(xué)版);2010年01期

5 徐峰;程坤;張春芳;;絕經(jīng)期婦女骨質(zhì)疏松癥的發(fā)病及中藥治療機理探究[J];中醫(yī)藥學(xué)報;2010年01期

6 陳偉才;羅軍;;杜仲葉提取物誘導(dǎo)羊骨髓間充質(zhì)干細胞成骨及抑制其成脂肪分化[J];中國組織工程研究與臨床康復(fù);2009年10期

7 劉曉青;崔燎;;防治骨質(zhì)疏松癥的藥物研究進展[J];中國骨質(zhì)疏松雜志;2009年02期

8 劉屏;王東曉;陳桂蕓;陳孟莉;;雞血藤單體化合物對造血祖細胞增殖的調(diào)控作用研究[J];中國藥理學(xué)通報;2007年06期

9 李俊華;潘子毅;;葛根素對絕經(jīng)后骨質(zhì)疏松癥患者血清IL-4、IL-6、IL-10和雌激素水平的影響[J];中國中醫(yī)骨傷科雜志;2007年05期

10 馬慶華;張鵬霞;郭紅艷;魏曉東;歐芹;;白術(shù)多糖對D-半乳糖致衰大鼠神經(jīng)細胞抗氧化作用研究[J];中國老年學(xué)雜志;2006年12期

，

本文編號：1736707