發(fā)布時(shí)間：2018-04-02 07:30

  本文選題：潰瘍性結(jié)腸炎　切入點(diǎn)：潰結(jié)方　出處：《山西中醫(yī)學(xué)院》2016年碩士論文

【摘要】：研究背景:現(xiàn)代生活變化日新月異,物質(zhì)生活水平有所提高,以及診斷技術(shù)的不斷提升,隨之改變的是UC的發(fā)病率逐年增高的趨勢(shì)在我國日益顯現(xiàn)。由于UC病變范圍相較其他疾病比較廣泛、易反復(fù)發(fā)作、常經(jīng)久不愈,癌變的可能性極大。因此,患者長期困擾于此,然而現(xiàn)代醫(yī)學(xué)對(duì)其治療效果不甚理想,世界衛(wèi)生組織已將其確認(rèn)為當(dāng)今難治性疾病。潰瘍性結(jié)腸炎的復(fù)發(fā)已然成為世界性的難題,采用中藥治療經(jīng)濟(jì)實(shí)用,進(jìn)而解除患者的病痛,有效提高其生活質(zhì)量。目的:觀察總結(jié)潰結(jié)方灌腸治療大腸濕熱型潰瘍性結(jié)腸炎中醫(yī)癥候的改善情況和臨床療效。方法:按照隨機(jī),對(duì)照的原則將收集山西省中醫(yī)院住院和門診病例中篩選出100例經(jīng)診斷為大腸濕熱型潰瘍性結(jié)腸炎的患者,將其按1:1隨機(jī)分為試驗(yàn)組和對(duì)照組。治療組給予潰結(jié)方1劑加生理鹽水60ml,保留灌腸1小時(shí),于每晚睡前一次;對(duì)照組給予美沙拉嗪灌腸液60ml,保留灌腸1小時(shí),于每晚睡前一次。8周為一個(gè)療程。從此治療開始(0天)至此治療結(jié)束(8周),共3次訪視。進(jìn)行臨床癥狀體征觀察,測(cè)定及血、尿、糞常規(guī)等安全性檢測(cè),待治療結(jié)束后評(píng)價(jià)其臨床療效和安全性。結(jié)果:治療前后兩組患者在性別、年齡、病情方面差異無統(tǒng)計(jì)學(xué)意義,具有可比較性。治療后兩組患者癥狀評(píng)分,在里急后重、腹痛、溲赤、口干口苦等方面,兩組間比較有明顯差異(P0.05),試驗(yàn)組優(yōu)于對(duì)照組;在安全性評(píng)價(jià)方面,試驗(yàn)組與對(duì)照組均無明顯不良反應(yīng)。結(jié)論:潰結(jié)方灌腸治療能明顯緩解大腸濕熱型潰瘍性結(jié)腸炎的癥狀、減輕腹痛、里急后重等不適感,即在改善大腸濕熱型潰瘍性結(jié)腸炎癥狀方面卓有成效,值得在臨床方面做更進(jìn)一步推廣。
[Abstract]:Background: modern life changes with each passing day, material living standard has been improved, and diagnostic technology has been improved. What changes with it is that the incidence of UC is increasing year by year in our country. As the range of UC lesions is more extensive than other diseases, it is easy to repeat attacks, often unhealed for a long time, and the possibility of canceration is great. Therefore, the patients have been troubled by this for a long time. However, the effect of modern medicine on its treatment is not satisfactory. The World Health Organization has recognized it as a refractory disease. The recurrence of ulcerative colitis has become a worldwide problem, and it is economical and practical to use traditional Chinese medicine to treat it. Objective: to observe and summarize the improvement and clinical effect of Kuijie prescription enema in treating ulcerative colitis of large intestine damp-heat type. According to the principle of control, 100 cases of ulcerative colitis of large intestine damp-heat type were selected from inpatients and outpatients of Shanxi traditional Chinese Medicine Hospital. The experimental group was randomly divided into experimental group and control group according to 1:1. The treatment group was given Kuijie prescription 1 dose plus normal saline 60 ml, retention enema for 1 hour, once a night before bedtime, the control group was given 60 ml mesalazine enema for 1 hour, and the control group was given 60 ml mesalazine enema for 1 hour. A course of 8 weeks before going to bed every night. From then on, the treatment began for 0 days.) at the end of 8 weeks of treatment, 3 visits were made. The clinical symptoms and signs were observed, and the safety of blood, urine, fecal routine, and so on were measured. Results: there was no significant difference in sex, age and condition between the two groups before and after treatment. The difference between the two groups was significant (P 0.05). The experimental group was superior to the control group, and the safety evaluation was better than that in the control group. Conclusion: Kuijiefang enema can relieve the symptoms of ulcerative colitis of damp-heat type of large intestine, relieve abdominal pain, and relieve the discomfort after acute and severe colitis. It is effective in improving the symptoms of colonic damp-heat ulcerative colitis, and it is worth further popularizing in clinic.
【學(xué)位授予單位】：山西中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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