本文選題：復發(fā)性口腔潰瘍　切入點：溫解湯　出處：《河南中醫(yī)藥大學》2016年碩士論文

【摘要】：目的:本實驗擬通過觀察溫解湯對復發(fā)性口腔潰瘍(RAU)患者癥狀、體征及T淋巴細胞亞群CD4、CD8及補體C3、C4的影響,并與臨床常用藥物羅紅霉素膠囊聯(lián)合維生素B2效果進行比較,綜合評價溫解湯,并進而探究其可能的作用機理,為臨床防治和新藥研發(fā)提供充分的理論支撐。方法:將2014年6月-2015年12月在河南中醫(yī)藥大學第三附屬醫(yī)院消化科、口腔科門診確診為RAU(寒熱錯雜型)的患者,共60例,按就診順序編為1-60號,隨機分為兩組,即溫解湯治療組、西藥對照組,各30例。治療組給予溫解湯,西藥對照組:羅紅霉素膠囊,維生素B2。治療10天后,評價其臨床癥狀、體征及安全性指標,并用實驗方法測量患者CD4、CD8及補體C3、C4的含量變化,繼續(xù)給藥5天鞏固治療,隨訪3個月。結果:1安全性:兩組患者心電圖及常規(guī)生化檢查無異常,未出現(xiàn)不良反應;2臨床證候:兩組患者口腔潰瘍面積、數(shù)目、疼痛程度、創(chuàng)面愈合情況等各項證候、體征較治療前均有改善P)05.0(,溫解湯治療組、西藥對照組總有效率分別為93%、86%,無顯著差異P)05.0(。3檢測指標:兩組患者在規(guī)范服藥一療程后,CD4及補體C3、C4水平均增高P)05.0(,CD8水平下降P)05.0(,且治療后溫解湯治療組與西藥對照組差異不明顯P)05.0(。4遠期療效:溫解湯治療組三月內(nèi)復發(fā)率%19,西藥對照組三月內(nèi)復發(fā)率高達%84,其差異有顯著統(tǒng)計學意義P)01.0(。結論:溫解湯治療RAU寒熱錯雜型,能大大縮短患者病程,緩解痛苦,降低復發(fā)率,在癥狀改善方面成果顯著。在規(guī)范治療一個療程后對CD4及血清補體C3、C4水平有上調(diào)作用,同時降低CD8水平,驗證了該指標與RAU的密切關系。與西藥對照組相比,局部病損恢復及證候療效相當,但在長期療效方面有顯著優(yōu)勢,且實驗中無明顯不良事件發(fā)生,效佳,安全無副作用。
[Abstract]:Objective: to observe the effects of Wenjie decoction on symptoms, signs, T lymphocyte subsets CD4C 8 and complement C 3 C 4 in patients with recurrent oral ulcer (Rau), and to compare the effects with roxithromycin capsule combined with vitamin B2. In order to provide sufficient theoretical support for clinical prevention and treatment and new drug research and development, Wenjie decoction was comprehensively evaluated and its possible mechanism was explored. Methods: from June 2014 to December 2015, Department of Digestive Sciences, third affiliated Hospital of Henan University of traditional Chinese Medicine, was selected. A total of 60 patients diagnosed as Rau (cold and heat disorder type) in outpatient department of stomatology were randomly divided into two groups: Wenjie decoction treatment group, western medicine control group, 30 cases each. The treatment group was given Wenjie decoction, and the western medicine control group was treated with Wenjie decoction. The western medicine control group: roxithromycin capsule, vitamin B2. After 10 days of treatment, the clinical symptoms, signs and safety indexes were evaluated, and the changes of CD _ 4, CD _ 8 and complement C _ 3N _ 4 were measured by the experimental method. Results: there was no abnormal electrocardiogram and routine biochemical examination, and no adverse reactions were found in the two groups: the area of oral ulcer, the number of patients, the degree of pain, wound healing and other syndromes in the two groups. The physical signs were improved before treatment, and the treatment group was treated with Wenjie decoction. The total effective rate of the western medicine control group was 935.86 and there was no significant difference between the two groups: after a course of standardized treatment, the levels of CD _ 4 and C _ 3N _ 4 in the two groups were increased, the levels of P _ (05.0) and CD _ 8 were decreased, and the difference between the treatment group and the western medicine control group was also found after the treatment. The long term curative effect of PX05.04.The relapse rate in the treatment group was higher than that in the western medicine control group, and the recurrence rate in the treatment group was as high as that in the western medicine control group. Conclusion: Wenjie decoction can shorten the course of disease, ease the pain and reduce the recurrence rate of RAU, which can greatly shorten the course of disease, alleviate the pain and reduce the recurrence rate. After a course of standardized treatment, the levels of CD4 and serum complement C _ 3N _ 4 were upregulated, and the level of CD8 was decreased, which verified the close relationship between the index and RAU. The recovery of local lesions and syndromes were similar, but there were significant advantages in long-term efficacy, and there were no obvious adverse events in the experiment, good effect, safety and no side effects.
【學位授予單位】：河南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R276.8

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