本文關(guān)鍵詞：Ⅱ型碳酸酐酶、活化T細(xì)胞核因子與老年男性骨質(zhì)疏松癥中醫(yī)證型關(guān)系的探討　出處：《福建中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 老年性骨質(zhì)疏松 骨密度 Ⅱ型碳酸酐酶 活化T細(xì)胞核因子 Ⅰ型前膠原氨基端延長肽 β-膠原特殊序列

【摘要】：目的：本研究通過分析老年男性骨質(zhì)疏松患者骨密度、骨代謝指標(biāo)、ⅡI型碳酸酐酶(CAⅡ)、活化T細(xì)胞核因子(NFAT2)等指標(biāo),研究老年男性骨質(zhì)疏松癥不同中醫(yī)證型與上述指標(biāo)是否存在關(guān)聯(lián),為老年男性原發(fā)性骨質(zhì)疏松辨證分型診斷提供幫助。方法：根據(jù)病例納入、排除標(biāo)準(zhǔn),從2015年03月至2015年09月在廈門大學(xué)附屬中山醫(yī)院老年科、康復(fù)科門診及病房就診的老年男性患者,檢測患者Ⅱ型碳酸酐酶(CAⅡ)、活化T細(xì)胞核因子(NFAT2)、β膠原特殊序列(β-crosslaps)、I型前膠原氨基端延長肽(P1NP)和股骨頸骨密度、腰椎L2-L4骨密度等指標(biāo),并與不同中醫(yī)證型進(jìn)行相關(guān)性分析,所錄入的數(shù)據(jù)采用SPSS21.0統(tǒng)計(jì)學(xué)軟件處理。結(jié)果：1、老年男性骨質(zhì)疏松患者股骨頸骨密度顯著低于非骨質(zhì)疏松患者(P0.01),其各中醫(yī)證型間均無差異(P0.05)2、腎陽虛型老年骨質(zhì)疏松患者L2-L4腰椎骨密度低于非骨質(zhì)疏松患者,但高于腎陰虛組及氣滯血瘀組(P均0.05)；氣滯血瘀組與腎陰虛組比較無差異(P=0.614)3、氣滯血瘀組β-crosslaps值明顯高于其他各組(腎陽虛組、腎陰虛組)(P均0.01)4、氣滯血瘀組P1NP較其他證型高,腎陽虛與腎陰虛組無差別(P=0.868)5、老年男性骨質(zhì)疏松癥中醫(yī)證型與血清CAII、NFAT2mRNA表達(dá)水平具有相關(guān)性：①氣滯血瘀組血清CAIImRNA表達(dá)水平高于腎陽虛組、腎陰虛組(P0.01)②腎陰虛組血清NFAT2mRNA表達(dá)水平高于氣滯血瘀組、腎陽虛組,且各組間比較具有顯著差異(P0.01)結(jié)論：1、各組骨密度結(jié)果與β-crosslaps呈反比,與P1NP結(jié)果呈正比,符合目前國內(nèi)外研究2、氣滯血瘀組CAIImRNA水平較高,股骨頸骨密度低于其他各骨質(zhì)疏松組,代表了破骨細(xì)胞較高的骨吸收能力,容易引發(fā)股骨頸骨折,體現(xiàn)了“因虛致瘀”的中醫(yī)觀點(diǎn)3、骨質(zhì)疏松患者NFAT2mRNA表達(dá)顯著升高,提示骨質(zhì)疏松患者破骨細(xì)胞分化形成過程相對活躍。其中腎陰虛組NFAT2mRNA表達(dá)量最高,可作為其區(qū)別其他證型的參考指標(biāo)之一。
[Abstract]:Objective: through the analysis of bone mineral density in elderly male patients with osteoporosis, bone metabolism, carbonic anhydrase II type I (CA II), the activation of nuclear factor T (NFAT2) and other indicators of different syndromes in elderly male patients with osteoporosis and the indicators of whether there is an association, for the elderly male patients with primary osteoporosis syndrome diagnostic help. Methods: according to inclusion and exclusion criteria, from the affiliated Zhongshan Hospital of geriatrics at the Xiamen University from 2015 03 to 2015 09 months, the elderly male patients with rehabilitation outpatient and ward treatment, detection of carbonic anhydrase in patients with type II (CA II), activation of nuclear factor T (NFAT2), beta collagen (special sequence beta -crosslaps), procollagen type I amino terminal peptide (P1NP) and bone mineral density of femoral neck, lumbar L2-L4 bone density index, and correlation analysis with different TCM syndromes, the input data by SPSS21.0 statistics Software. Results: 1 elderly male osteoporosis patients with femoral neck BMD was significantly lower than that in patients with osteoporosis (P0.01), there were no differences between the TCM syndrome type 2 (P0.05), kidney yang deficiency type senile osteoporosis patients with L2-L4 bone mineral density is lower than the non osteoporosis patients, but higher than kidney Yin deficiency group and qi stagnation blood stasis group (P 0.05); Qi stagnation and blood stasis group and kidney yin deficiency group had no difference (P=0.614 3), blood stasis group -crosslaps beta value was significantly higher than other groups (kidney yang deficiency group, kidney yin deficiency group) (P 0.01) 4, qi stagnation and blood stasis group P1NP than the other syndromes, kidney yang deficiency and kidney yin deficiency there was no difference (P=0.868 5), the syndrome and serum CAII in elderly male osteoporosis, with the correlation between the expression level of NFAT2mRNA: the expression of qi stagnation and blood stasis had higher serum CAIImRNA level in kidney yang deficiency group, kidney yin deficiency group (P0.01), kidney yin deficiency group serum NFAT2mRNA expression level is higher than that of gas Stagnation of blood stasis group, kidney yang deficiency group, and the comparison between groups had significant difference (P0.01) conclusion: the 1 groups, the results of bone mineral density and beta was inversely proportional to -crosslaps, and is proportional to the P1NP results, in line with the current domestic and foreign research 2, qi stagnation and blood stasis group CAIImRNA level is higher, femoral neck BMD is lower than other osteoporosis group. On behalf of the osteoclast high ability of bone resorption, easily lead to femoral neck fracture, embodies the "because of the viewpoint of Chinese medicine Qi Deficiency" 3, the expression of NFAT2mRNA was significantly increased in patients with osteoporosis and osteoporosis patients with the differentiation of osteoclast formation process is relatively active. The expression of NFAT2mRNA was highest in kidney yin deficiency group, can be used as one of the the difference between the reference index of other syndromes.

【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

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本文編號：1372918