炎癥性腸�。↖nflammatory bowel disease,IBD）是一種原因尚不明確的腸道慢性炎癥性疾病,具有終身復(fù)發(fā)的傾向,主要包括潰瘍性結(jié)腸炎（Ulcerative colitis,UC）和克羅恩�。–rohn’s disease,CD）兩種類型。研究證實(shí)IBD是結(jié)直腸癌發(fā)生的確切危險(xiǎn)因素之一,病程10年、20年及30年的潰瘍性結(jié)腸炎患者發(fā)生癌變的風(fēng)險(xiǎn)分別為1.2%、3.6%和14.4%,IBD患者平均發(fā)生結(jié)直腸癌危險(xiǎn)度為普通人群的2-4倍,每年平均約有10-15%的IBD患者死于結(jié)直腸癌,這種由炎癥導(dǎo)致的結(jié)直腸癌是IBD最為嚴(yán)重的并發(fā)癥,嚴(yán)重威脅著人們的生命健康。而由炎癥演變而來的結(jié)直腸癌與散發(fā)性結(jié)直腸癌相比,在發(fā)病機(jī)制、臨床特征、病理類型等方面存在明顯的不同,因此人們將由結(jié)腸炎演變而來的結(jié)直腸癌統(tǒng)稱為炎癥相關(guān)結(jié)腸癌（colitis-associated colorectal cancer,CAC）。炎癥相關(guān)結(jié)直腸癌的發(fā)生通常需要經(jīng)歷“炎癥→異型增生→癌”的過程,炎癥是CAC發(fā)生的始動(dòng)因素。作為參與炎癥最重要炎癥介質(zhì)-腫瘤因子（Tumor necrosis factor,... 

【文章來源】：河北醫(yī)科大學(xué)河北省

【文章頁數(shù)】：116 頁

【學(xué)位級(jí)別】：博士

【部分圖文】：

淋系高表達(dá)TL1A小鼠的鑒定

圖 1-2 淋系高表達(dá)TL1A小鼠在AOM+DSS模型中炎癥程度較重Fig.1-2 TL1A overexpression mices are more susceptible to AOM+DSSinduced colitis，WT and Tg mice were injected with AOM and treated withfour rounds of DSS for 7days （A）Body weight changes of WT and Tg mice（B）DAI which is consisting of weight loss, stool consistency and FOB, wasmeasured daily. The AOM+DSS/Tg group displayed much severerinflammation compared with AOM+DSS/WT group (2.3±0.76 vs 1.28±0.47,P<0.05) （C）The colonic tissue became hard, poor elasticity, mucouscongestion and edema, localized stenosis, and the size of nodular eminencewas seen, and the lumen suddenly entered the lumen. AOM+DSS/Tg comparewith AOM+DSS/WT, the weight loss was more obvious (7.00cm±0.97cm vs5.85 ± 0.78cm, P<0.05);(D)The AOM+DSS/Tg group. compared withAOM+DSS/ WT group, the dysplasia score was higher (P < 0.05).

圖1-3 TL1A促進(jìn)炎癥相關(guān)結(jié)直腸癌的發(fā)生和發(fā)展Fig.1-3 TL1A promotes the development of inflammation related colorectcancer （A）tumor number in AOM+DSS/Tg group were obviously highthan that in AOM+DSS/WT group (3.50±1.19 vs 5.62±1.30, P<0.05), (Bcompared with the mice in control group, in AOM+DSS group the size of ceis different, the level of the cells is disordered, the polarity disappeared, thgoblet cells decreased, the nuclei increased, and the nuclear fission increaseThe normal structure disappears and the abnormal hyperplasia is obvious. (Ctumor formation rate of AOM+DSS/Tg group was obviously higher than thin AOM+DSS/WT group (88.9% vs 66.7%) (D). According to the degree intestinal mucosa cell dysplasia scores, the AOM+DSS/Tg group wsignificantly higher than AOM+DSS/WT group (2.75±0.5 vs 1.70±0.P<0.05).

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博士論文
[1]促炎因子和益生菌調(diào)控Wnt/β-catenin信號(hào)通路相關(guān)機(jī)制研究[D]. 徐天銘.北京協(xié)和醫(yī)學(xué)院 2016
[2]維生素D3對急性結(jié)腸炎及炎癥相關(guān)結(jié)直腸癌小鼠模型的干預(yù)研究及機(jī)制初探[D]. 周穎.北京協(xié)和醫(yī)學(xué)院 2015
[3]潰瘍性結(jié)腸炎相關(guān)性結(jié)腸癌發(fā)病機(jī)制初探[D]. 鄭威揚(yáng).北京協(xié)和醫(yī)學(xué)院 2009

碩士論文
[1]潰瘍性結(jié)腸炎癌變機(jī)制的研究及結(jié)直腸息肉危險(xiǎn)因素分析[D]. 李艷萍.北京協(xié)和醫(yī)學(xué)院 2014



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