發(fā)布時間：2019-08-01 10:22

【摘要】：外泌體是一種細胞分泌的具有雙層脂質(zhì)膜結(jié)構(gòu)的納米級小囊泡,幾乎所有類型的細胞均可分泌外泌體.外泌體攜帶核酸和蛋白質(zhì)等多種具有生物活性的內(nèi)容物,不但在細胞間信息交流和信號轉(zhuǎn)導(dǎo)的過程中起著重要作用,而且參與了人體內(nèi)各種病理生理過程.腫瘤來源的外泌體參與調(diào)控腫瘤的生長發(fā)展和侵襲轉(zhuǎn)移等過程.外泌體在腫瘤的早期診斷、預(yù)后判斷以及作為治療工具方面的探索已經(jīng)成為研究熱點.對外泌體在腫瘤的發(fā)生發(fā)展、轉(zhuǎn)移侵襲以及在腫瘤精準診斷與個體化治療方面的進展作一綜述.
[Abstract]:Exocrine is a kind of nanoscale vesicle secreted by cells with bilayer lipid membrane structure, and almost all types of cells can secrete exocrine. Exocrine carries nucleic acid, protein and other bioactive contents, which not only play an important role in the process of information exchange and signal transduction between cells, but also participate in various pathophysiological processes in the human body. Exocrine from tumor source is involved in the regulation of tumor growth, development, invasion and metastasis. Exocrine has become a hot research topic in the early diagnosis, prognosis and treatment of tumors. The progress of exocrine system in the occurrence and development of tumor, metastasis and invasion, as well as in accurate diagnosis and individualized treatment of tumor is reviewed.
【作者單位】： 同濟大學(xué)附屬同濟醫(yī)院普外科;溫州醫(yī)科大學(xué)附屬第一醫(yī)院皮膚科;同濟大學(xué)附屬同濟醫(yī)院消化內(nèi)科;
【基金】：國家自然科學(xué)基金資助項目(81370559,81370586,81670571) 上海市重要疾病聯(lián)合攻關(guān)重大項目(2014ZYJB0201) 上海市新興前沿技術(shù)聯(lián)合攻關(guān)項目(SHDC12014122)
【分類號】：R730
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本文編號：2521688