疏肝和胃穴位埋線法干預(yù)化療延遲性嘔吐的臨床研究
發(fā)布時間：2019-07-08 15:16
【摘要】：目的:探討疏肝和胃穴位埋線法對消化系腫瘤化療所致的延遲性嘔吐的臨床療效。方法:采用前瞻性臨床隨機(jī)對照方法。將60例使用中-高致吐風(fēng)險化療方案的消化系腫瘤患者,按數(shù)字隨機(jī)法分為觀察組和對照組,各30例。觀察組以穴位埋線+西醫(yī)止吐,對照組以單純西醫(yī)止吐。兩組患者所用化療藥物均含有順鉑或蒽環(huán)類或奧沙利鉑或氟尿嘧啶或紫杉醇等,具有中-高致吐風(fēng)險。觀察兩組患者治療后惡心嘔吐的療效差異。結(jié)果:1.在化療前,觀察組及對照組在性別、年齡、病種、腫瘤分期上基線一致,無明顯統(tǒng)計學(xué)差異,兩組患者具有可比性。2.在急性嘔吐上,觀察組與對照組嘔吐發(fā)生率無統(tǒng)計學(xué)差異(93.33%vs.96.67%,p0.05);在延遲性嘔吐上,化療后d4~d6,觀察組嘔吐發(fā)生率分別為43.33%、50.00%、53.33%明顯低于對照組60%、73.33%、76.66%,差異具有統(tǒng)計學(xué)意義(P0.05)。3.在控制惡心嘔吐療效上,觀察組有效率為83.33%,明顯優(yōu)于對照組70%,具有統(tǒng)計學(xué)差異(P0.05)。4.治療后,兩組患者的KPS(健康狀況)評分均較化療前有所下降,觀察組治療前后無明顯差異(P0.05),而對照組下降較明顯(P0.05);即觀察組健康狀況狀況明顯優(yōu)于對照組。5.治療后,兩組患者的QOL(生活質(zhì)量)評分均較化療前有所下降,觀察組治療前后無明顯差異(P0.05),而對照組下降較明顯(P0.05);即觀察組生活質(zhì)量狀況明顯優(yōu)于對照組。結(jié)論:疏肝和胃穴位埋線法聯(lián)合西醫(yī)止吐藥物在防治中-高致吐風(fēng)險化療所致的延遲性嘔吐,明顯優(yōu)于單純西醫(yī)止吐方案,能夠提高惡性腫瘤化療期患者的健康狀況及生活質(zhì)量,值得臨床廣泛推廣運用。
[Abstract]:Objective: To study the clinical effect of liver-soothing and stomach-point line-embedding method on the delayed vomiting induced by chemotherapy in the digestive system. Methods: A prospective, randomized, controlled method was used. 60 patients with digestive system with high-risk chemotherapy were divided into the observation group and the control group according to the digital random method. In the observation group, the point buried line + western medicine anti-vomiting, and the control group was treated with pure western medicine to stop vomiting. The chemotherapy drugs used in both groups contain cisplatin or carbocyclic or oxaliplatin or fluurine or paclitaxel or the like, and have moderate-high-to-discharge risk. The curative effect of nausea and vomiting after treatment was observed in two groups. Results:1. Before and after the chemotherapy, the baseline of sex, age, disease and tumor in the observation group and the control group were consistent and there was no significant statistical difference, and the two groups were comparable. The incidence of vomiting in the observation group and the control group was no statistical difference (93.33% vs. 96.67%, p0.05) in the case of acute vomiting, and the incidence of vomiting in the observation group was 43.33%, 50.00% and 53.33%, which was significantly lower than that of the control group, 73.33% and 76.66%, respectively. The difference was statistically significant (P0.05). In the treatment of nausea and vomiting, the effective rate of the observation group was 83.33%, which was significantly better than that of the control group (70%, P <0.05). After the treatment, the scores of KPS (health status) of the two groups were lower than that before chemotherapy, and there was no significant difference before and after the treatment (P0.05), and the control group had a significant decrease (P0.05); that is, the health status of the observation group was significantly better than that of the control group. The QOL (quality of life) of the two groups was lower than that of the control group after the treatment, and there was no significant difference before and after the treatment (P0.05), and the control group was significantly lower than that in the control group (P0.05). Conclusion: The delayed vomiting caused by the combination of the liver-soothing and the stomach-point line-embedding method in the prevention and treatment of the high-risk chemotherapy of the western medicine is superior to that of the simple western medicine anti-emetic scheme, and can improve the health status and the quality of life of the patients with the chemotherapy period of the malignant tumor, and is worthy of wide-scale popularization and application.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R735
本文編號：2511679
[Abstract]:Objective: To study the clinical effect of liver-soothing and stomach-point line-embedding method on the delayed vomiting induced by chemotherapy in the digestive system. Methods: A prospective, randomized, controlled method was used. 60 patients with digestive system with high-risk chemotherapy were divided into the observation group and the control group according to the digital random method. In the observation group, the point buried line + western medicine anti-vomiting, and the control group was treated with pure western medicine to stop vomiting. The chemotherapy drugs used in both groups contain cisplatin or carbocyclic or oxaliplatin or fluurine or paclitaxel or the like, and have moderate-high-to-discharge risk. The curative effect of nausea and vomiting after treatment was observed in two groups. Results:1. Before and after the chemotherapy, the baseline of sex, age, disease and tumor in the observation group and the control group were consistent and there was no significant statistical difference, and the two groups were comparable. The incidence of vomiting in the observation group and the control group was no statistical difference (93.33% vs. 96.67%, p0.05) in the case of acute vomiting, and the incidence of vomiting in the observation group was 43.33%, 50.00% and 53.33%, which was significantly lower than that of the control group, 73.33% and 76.66%, respectively. The difference was statistically significant (P0.05). In the treatment of nausea and vomiting, the effective rate of the observation group was 83.33%, which was significantly better than that of the control group (70%, P <0.05). After the treatment, the scores of KPS (health status) of the two groups were lower than that before chemotherapy, and there was no significant difference before and after the treatment (P0.05), and the control group had a significant decrease (P0.05); that is, the health status of the observation group was significantly better than that of the control group. The QOL (quality of life) of the two groups was lower than that of the control group after the treatment, and there was no significant difference before and after the treatment (P0.05), and the control group was significantly lower than that in the control group (P0.05). Conclusion: The delayed vomiting caused by the combination of the liver-soothing and the stomach-point line-embedding method in the prevention and treatment of the high-risk chemotherapy of the western medicine is superior to that of the simple western medicine anti-emetic scheme, and can improve the health status and the quality of life of the patients with the chemotherapy period of the malignant tumor, and is worthy of wide-scale popularization and application.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R735
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