【摘要】：目的:觀察珍珠燒傷膏在治療乳腺癌術后皮瓣壞死創(chuàng)面不愈中促進愈合的療效,尋找一種好的治療創(chuàng)面不愈的方法。方法:病例來源于2009年06月—2016年12月期間就診于吉林大學中日聯(lián)誼醫(yī)院乳腺外科的乳腺癌術后皮瓣壞死創(chuàng)面不愈的患者。按照隨機原則把納入的252例乳腺癌術后皮瓣壞死創(chuàng)面不愈的患者作為研究對象,均符合納入及排除標準,使用隨機數(shù)字表法按患者先后入院時間編號,治療組為130人,對照組為122人。治療組運用珍珠燒傷膏治療乳腺癌術后皮瓣壞死創(chuàng)面不愈,對照組運用生理鹽水紗布外敷。統(tǒng)計分析治療組與對照組總體愈合情況。另外,探討全身及局部因素對珍珠燒傷膏治療乳腺癌術后皮瓣壞死創(chuàng)面不愈的影響。換藥期間詳細觀察創(chuàng)面愈合及肉芽組織生長情況。結果:1、治療組與對照組總體愈合率比較,差異具有統(tǒng)計學意義(p0.05)。2、60歲患者中治療組與對照組愈合率比較,差異具有統(tǒng)計學意義(p0.05);≥60歲患者中治療組與對照組愈合率比較,差異不具有統(tǒng)計學意義(p0.05)。3、糖尿病患者中治療組與對照組愈合率比較,差異不具有統(tǒng)計學意義(p0.05);非糖尿病患者中治療組與對照組愈合率比較,差異具有統(tǒng)計學意義(p0.05)。4、肥胖型患者中治療組與對照組愈合率比較,差異具有統(tǒng)計學意義(p0.05);非肥胖型患者中治療組與對照組愈合率比較,差異同樣具有統(tǒng)計學意義(p0.05)。5、創(chuàng)面缺損大小≤5.0cm患者中治療組與對照組愈合率比較,差異具有統(tǒng)計學意義(p0.05);創(chuàng)面缺損大小5.0cm患者中治療組與對照組愈合率比較,差異不具有統(tǒng)計學意義(p0.05)。結論:1、珍珠燒傷膏治療乳腺癌術后皮瓣壞死創(chuàng)面不愈能夠提高總體愈合率。2、珍珠燒傷膏對治療非老年及肥胖型患者乳腺癌術后皮瓣壞死創(chuàng)面不愈有效。3、針對患者乳腺癌術后出現(xiàn)皮瓣壞死創(chuàng)面缺損較大(寬度5.0cm)、為老年女性、糖尿病診斷明確,珍珠燒傷膏療效不明顯。
[Abstract]:Objective: to observe the effect of pearl burn ointment in the treatment of skin flap necrosis wound healing after breast cancer operation, and to find a good method to treat wound nonhealing. Methods: the case was from June 2009 to December 2016 in the breast surgery department of China-Japan United Hospital of Jilin University. According to the principle of randomization, 252 patients with unhealed skin flap after breast cancer surgery were enrolled in the study, all of which met the criteria of inclusion and exclusion. According to the admission time of the patients, 130 patients in the treatment group and 122 patients in the control group were enrolled in the random digital table method. The treatment group was treated with pearl burn ointment, while the control group was treated with saline gauze. The overall healing of the treatment group and the control group was statistically analyzed. In addition, to investigate the effect of whole body and local factors on the treatment of skin flap necrosis wound with pearl burn ointment after breast cancer surgery. Wound healing and granulation tissue growth were observed in detail during dressing change. Results: 1 there was significant difference in the overall healing rate between the treatment group and the control group (p0.05). 2, there was significant difference between the treatment group and the control group in the healing rate between the treatment group and the control group (p0.05). There was no significant difference in the healing rate between the treatment group and the control group (p0.05). 3. There was no significant difference in the healing rate between the treatment group and the control group (p0.05). There was significant difference in healing rate between treatment group and control group in non-diabetic patients (p0.05). 4. There was significant difference in healing rate between treatment group and control group in obese patients (p0.05). There was also significant difference in healing rate between treatment group and control group in non-obese patients (p0.05). 5. There was significant difference in healing rate between treatment group and control group in patients with wound defect size 鈮，

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