【摘要】：目的:研究抗紡錘體(MSA)和抗著絲點(ACA)抗體檢測對診斷小細胞性肺癌(SCLC)的臨床價值,為SCLC的分子研究提供臨床依據(jù)。方法:對93例SCLC患者和208例非小細胞性肺癌(NO-SCLC)患者及50例健康體檢者,用酶聯(lián)免疫法定量檢測MSA抗體,間接免疫熒光法定性檢測MSA、ACA和抗核抗體(ANA),并對其結(jié)果進行回顧性分析。結(jié)果:1IIF法檢測SCLC組MSA和ACA陽性率為36.56%和30.11%,均高于其他腫瘤組(P0.01)。2相關(guān)性分析,MSA與SCLC的RR值高達12.93、12.74,ACA和ANA與SCLC的RR值為4.31和3.48。3MSA檢測SCLC的ROC曲線下面積AUC為0.778,診斷價值中等。結(jié)論:MSA和ACA對SCLC有很強正相關(guān)危險因素,可能參與SCLC的發(fā)生發(fā)展,對SCLC的早期檢測、臨床診斷及潛在的治療方法有一定的應(yīng)用價值。
[Abstract]:Objective: to study the clinical value of antispindle (MSA) and anti-centromere (ACA) antibody in the diagnosis of small cell lung cancer (SCLC), and to provide clinical basis for the molecular study of SCLC. Methods: MSA antibody was detected quantitatively by enzyme-linked immunosorbent assay (Elisa) in 93 patients with SCLC, 208 patients with non-small cell lung cancer (NO-SCLC) and 50 healthy controls. MSA,ACA and antinuclear antibody (ANA), were detected qualitatively by indirect immunofluorescence assay. The results were analyzed retrospectively. Results: the positive rates of MSA and ACA in SCLC group were 36.56% and 30.11%, which were higher than those in other tumor groups (P01). 2 correlation analysis showed that the RR value of MSA and SCLC was 12.93 and 12.74, respectively. The RR values of ACA, ANA and SCLC were 4.31 and the area AUC under ROC curve of SCLC detected by 3.48.3MSA was 0.778, which was of medium diagnostic value. Conclusion: MSA and ACA have strong positive correlation risk factors for SCLC, may be involved in the occurrence and development of SCLC, and have certain application value for early detection, clinical diagnosis and potential treatment of SCLC.
【作者單位】： 南昌大學第二附屬醫(yī)院檢驗科;南昌大學醫(yī)學院;
【基金】：江西省科技廳社發(fā)項目(No.2015BBG70154) 江西省科技廳重點科技成果轉(zhuǎn)移轉(zhuǎn)化計劃(No.20151BBI90047) 江西省衛(wèi)生廳科研計劃支持項目(No.20133075、20151072)
【分類號】：R734.2

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