發(fā)布時(shí)間：2019-05-09 14:14

【摘要】：目的：分析影響晚期結(jié)直腸癌患者的療效及預(yù)后的因素。方法：通過病例資料回顧和隨訪,回顧性分析2004年1月至2014年12月收治的222例晚期結(jié)直腸癌患者資料,對(duì)患者各項(xiàng)臨床因素使用Log-rank法(單因素分析)及Cox模型(多變量分析),統(tǒng)計(jì)這些因素與預(yù)后之間的相關(guān)性。結(jié)果：(1)年齡、是否手術(shù)、是否化療、CEA、CA199與患者總生存期存在相關(guān)性,其中年齡、是否手術(shù)、是否化療存在極顯著的相關(guān)性；(2)年齡、是否化療、CA199、 CEA、手術(shù)方式等5個(gè)因素是影響晚期結(jié)直腸癌預(yù)后的主要因素,其中CEA及手術(shù)方式顯著影響；(3)手術(shù)患者的生存時(shí)間明顯長于未手術(shù)的患者,其中原發(fā)灶切除+轉(zhuǎn)移灶切除患者的總生存時(shí)間原發(fā)灶切除患者的總生存時(shí)間姑息手術(shù)患者的總生存時(shí)間,手術(shù)加上射頻的患者的近期療效好于單單手術(shù)的患者能夠獲得更好的近期療效。結(jié)論：年齡60歲、化療、CA199≤37IU/ml、CEA≤5ng/ml、手術(shù)等5個(gè)因素是可以延長晚期結(jié)直腸癌的總生存時(shí)間；手術(shù)加上射頻的患者能夠獲得更好的近期療效；三種手術(shù)方式中,原發(fā)灶切除+轉(zhuǎn)移灶切除患者的預(yù)后更好。
[Abstract]:Objective: to analyze the factors affecting the curative effect and prognosis of patients with advanced colorectal cancer. Methods: the data of 222 patients with advanced colorectal cancer admitted from January 2004 to December 2014 were retrospectively reviewed and followed up. Log-rank method (univariate analysis) and Cox model (multivariate analysis) were used to analyze the correlation between these factors and prognosis. Results: (1) there was a significant correlation between age, operation, chemotherapy, CEA,CA199 and overall survival time, including age, operation and chemotherapy. (2) Age, chemotherapy and CA199, CEA, operation were the main factors influencing the prognosis of advanced colorectal cancer, among which CEA and operation mode were significantly affected. (3) the survival time of the patients undergoing operation was significantly longer than that of the patients without operation, among which the total survival time of the patients with primary tumor resection and metastasis resection was significantly longer than that of the patients without operation, and the total survival time of the patients with primary tumor resection and palliative surgery was significantly longer than that of the patients without operation. Patients who received surgery plus radiofrequency had better short-term outcomes than patients with surgery alone. Conclusion: the age of 60 years old, chemotherapy, CA199 37 IU / ml,CEA 鈮，

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