【摘要】：目的探討血清中白細胞介素-6(IL-6)和IL-22對早期乙型病毒性肝炎相關肝細胞癌患者(HBV-HCC)微波消融(MWA)治療后復發(fā)的預測作用。方法收集49例經(jīng)MWA治療早期HBVHCC患者術前外周血,應用ELISA檢測外周血IL-6與IL-22的含量,同期30例健康人作對照。據(jù)x-tile軟件計算cut-off值將IL-6和IL-22水平分為高水平組和低水平組,Kaplan-Meier分析兩組的無瘤生存期,Log rank檢驗差異性,Cox回歸篩選影響HBV-HCC復發(fā)的危險因素。結果 HCC組的IL-6與IL-22水平明顯高于對照組(IL-6:13.20(11.87~15.79)pg/ml和10.47(9.50~13.82)pg/ml,P=0.001;IL-22:42.18(34.39~57.44)pg/ml和25.45(22.31~30.12)pg/ml,P0.001)。Kaplan-Meier分析顯示HCC患者術前低IL-6、高總膽紅素和低白蛋白水平預示較短無瘤生存期,IL-22對HCC復發(fā)的影響差異無統(tǒng)計學意義。Cox回歸多因素分析顯示低IL-6(≤13.2 pg/ml,HR:3.721,95%CI:1.674~8.272,P=0.001)與低白蛋白水平(≤41.0 g/L,HR:2.085,95%CI:1.101~3.950,P=0.024)是影響肝癌復發(fā)的獨立危險因素。結論術前IL-6和白蛋白水平可作為MWA治療HBV-HCC患者預測復發(fā)的指標。
[Abstract]:Objective to investigate the predictive effect of serum interleukin-6 (IL-6) and IL-22 on recurrence after microwave ablation of (MWA) in patients with early hepatitis B-associated hepatocellular carcinoma (HBV-HCC). Methods Peripheral blood samples were collected from 49 patients with early HBVHCC treated with MWA. The levels of IL-6 and IL-22 in peripheral blood were measured by ELISA, and 30 healthy subjects were served as control at the same time. According to cut-off calculated by x-tile software, IL-6 and IL-22 levels were divided into two groups: high level group and low level group. The difference of, Log rank test for tumor-free survival between the two groups was analyzed by Kaplan-Meier. The risk factors of HBV-HCC recurrence were screened by Cox regression. Results the levels of IL-6 and IL-22 in HCC group were significantly higher than those in control group (IL-6:13.20 (11.87? 15.79) pg/ml and 10.47 (9.50? 13.82) pg/ml,P=0.001;). IL-22:42.18 (34.39? 57.44) pg/ml and 25.45 (22.31? 30.12) pg/ml,P0.001. Kaplan-Meier analysis showed that low IL-6, high total bilirubin and low albumin levels predicted shorter tumor-free survival time in patients with HCC. Cox regression multivariate analysis showed that low IL-6 (鈮，

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