發(fā)布時(shí)間：2019-03-05 16:09

【摘要】：目的檢測(cè)巨噬細(xì)胞集落刺激因子(M-CSF)在宮頸癌及宮頸上皮內(nèi)瘤變(CIN)患者血清中的表達(dá)水平,探討其在宮頸癌發(fā)展過(guò)程中的作用及早期診斷中的價(jià)值。方法選擇2014年6月至2016年6月間確診的宮頸癌患者49例、CIN患者60例、健康體檢者40例為研究對(duì)象,采取血清標(biāo)本,分別運(yùn)用ELISA及MEIA法檢測(cè)M-CSF、SCC-Ag表達(dá)水平。結(jié)果 M-CSF和SCCAg在宮頸癌患者血清中表達(dá)水平顯著高于健康對(duì)照組及CIN組(均P0.01)。M-CSF在CIN組的表達(dá)顯著高于正常對(duì)照組(P0.05),且高級(jí)別CIN組顯著高于低級(jí)別CIN組(P0.05),但SCC-Ag在CIN組及正常對(duì)照組的表達(dá)差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。聯(lián)合檢測(cè)SCC-A和M-CSF顯著提高宮頸癌檢出率。M-CSF在宮頸癌及高級(jí)別CIN患者術(shù)后均降低至正常水平,手術(shù)前后相比差異有統(tǒng)計(jì)學(xué)意義(P0.05),SCCAg則只有在宮頸癌組手術(shù)前、后表達(dá)差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 M-CSF可能成為宮頸癌和CIN診斷中有用的血清學(xué)指標(biāo),可望用于預(yù)測(cè)CIN和宮頸癌的轉(zhuǎn)歸。
[Abstract]:Aim to detect the expression of macrophage colony stimulating factor (M-CSF) in serum of patients with cervical cancer and cervical intraepithelial neoplasia (CIN), and to explore its role in the development of cervical cancer and its value in early diagnosis. Methods from June 2014 to June 2016, 49 patients with cervical cancer, 60 patients with CIN and 40 healthy subjects were selected as the subjects. Serum samples were taken to detect the expression of MC-CSF and SCC-Ag by ELISA and MEIA, respectively. Results the expression level of M-CSF and SCCAg in serum of cervical cancer patients was significantly higher than that of healthy control group and CIN group (P0.01), and the expression of M-CSF in CIN group was significantly higher than that of normal control group (P0.05). The expression of SCC-Ag in the high-grade CIN group was significantly higher than that in the low-grade CIN group (P0.05), but there was no significant difference in the expression of SCC-Ag between the CIN group and the normal control group (P0.05). Combined detection of SCC-A and M-CSF significantly increased the detection rate of cervical cancer. M-CSF decreased to normal level in cervical cancer and high-grade CIN patients after operation, and the difference was statistically significant before and after operation (P0.05). There was significant difference in SCCAg expression only before and after operation in cervical cancer group (P0.05). Conclusion M-CSF may be a useful serological marker in the diagnosis of cervical cancer and CIN, and can be used to predict the prognosis of CIN and cervical cancer.
【作者單位】： 南方醫(yī)科大學(xué)附屬佛山市婦幼保健院婦科;
【基金】：廣東省醫(yī)學(xué)科研基金(編號(hào):A2014703)
【分類(lèi)號(hào)】：R737.33

【相似文獻(xiàn)】

相關(guān)博士學(xué)位論文 前1條

1 南林;宮頸癌調(diào)強(qiáng)放療副作用分析[D];北京協(xié)和醫(yī)學(xué)院;2017年

相關(guān)碩士學(xué)位論文 前1條

1 帥汝臻;人乳頭瘤病毒E6/E7mRNA檢測(cè)對(duì)宮頸病變分層管理的臨床意義[D];寧夏醫(yī)科大學(xué);2017年

，

本文編號(hào)：2435081