【摘要】：目的:觀察腕踝針預(yù)防含順鉑化療后患者嘔吐的臨床療效。方法:按照相關(guān)的診斷標(biāo)準(zhǔn)和樣本量的計算方法,將入組的45例接受含順鉑化療的患者按照隨機數(shù)字表分為兩組,對照組23例在順鉑化療前給以標(biāo)準(zhǔn)治療(地塞米松+托烷司瓊),治療組22例以標(biāo)準(zhǔn)治療加腕踝針治療,觀察兩組嘔吐發(fā)生率、緩解率、臨床癥狀評分及KPS評分。結(jié)果:(1)一般資料分析:隨機入組后對兩組年齡、BMI、舒張壓、收縮壓、呼吸、心率、體溫、病程經(jīng)兩獨立樣本t檢驗,兩組差異均無統(tǒng)計學(xué)意義(P㧐0.05)。性別、民族、過敏史、用藥史、既往史、合并用藥經(jīng)χ2檢驗,兩組差異均無統(tǒng)計學(xué)意義(P0.05)。此結(jié)果表明兩組之間差異不具有統(tǒng)計學(xué)意義,具有一定的可比性;(2)評估臨床治療效果:(1)兩組的嘔吐及惡心發(fā)生率在第三天經(jīng)秩和檢驗,P0.05,在第一、第二、第四及第五天,P0.05;(2)兩組的中醫(yī)證候療效經(jīng)秩和檢驗,P0.05;(3)兩組KPS的變化經(jīng)秩和檢驗,P0.05,得知療效不顯著;治療組嘔吐及惡心情況在第三天與對照組的差異有統(tǒng)計學(xué)意義(P0.05),其余四日兩組間無統(tǒng)計學(xué)差異。結(jié)論:腕踝針在治療順鉑引起的延遲性嘔吐方面有著一定療效,且有較高安全性。
[Abstract]:Objective: to observe the clinical effect of wrist ankle acupuncture on preventing vomiting after chemotherapy with cisplatin. Methods: according to the relevant diagnostic criteria and the calculation method of sample size, 45 patients who received cisplatin-containing chemotherapy were divided into two groups according to the randomized numerical table. The control group (23 cases) received standard treatment (dexamethasone tropisetron) before cisplatin chemotherapy, and the treatment group (22 cases) received standard therapy plus wrist ankle acupuncture. The incidence of vomiting, remission rate, clinical symptom score and KPS score were observed. Results: (1) General data analysis: there was no significant difference in age, BMI, diastolic blood pressure, systolic blood pressure, respiration, heart rate, body temperature and course of disease between the two groups after two independent samples t test (P0. 05). There was no significant difference between the two groups in sex, nationality, allergic history, medication history, past history, combined use of drugs by 蠂 2 test (P0.05). The results show that the differences between the two groups are not statistically significant and have certain comparability. (2) Evaluation of clinical efficacy: (1) the incidence of vomiting and nausea in the two groups was tested by rank sum test on the third day (P0.05), and on the first, second, fourth and fifth days, P0.05; (2) the curative effect of TCM syndromes in the two groups was tested by rank sum test (P0.05), (3) the change of KPS in the two groups was tested by rank sum test (P0.05), and it was found that the curative effect was not significant. The vomiting and nausea in the treatment group were significantly different from those in the control group on the 3rd day (P0.05), but there was no significant difference between the two groups on the other 4 days. Conclusion: wrist ankle acupuncture is effective and safe in the treatment of delayed vomiting induced by cisplatin.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R734.2

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