【摘要】：目的比較神經(jīng)激肽-1受體抑制劑阿瑞匹坦三聯(lián)方案與傳統(tǒng)兩聯(lián)方案預(yù)防中高度催吐化療方案分次給藥所致惡心嘔吐的療效和安全性。方法對(duì)102例化療患者前瞻性對(duì)照研究的數(shù)據(jù)進(jìn)行中期分析,其中49例患者接受5-羥色胺-3受體抑制劑聯(lián)合和托烷司瓊兩聯(lián)止吐方案,53例患者接受神經(jīng)激肽-1受體抑制劑阿瑞匹坦聯(lián)合5-羥色胺-3受體抑制劑和托烷司瓊的三聯(lián)止吐方案;采用KaplanMeier曲線比較兩組第一次嘔吐發(fā)生時(shí)間,FLIE量表評(píng)價(jià)惡心嘔吐生活質(zhì)量;評(píng)價(jià)阿瑞匹坦的相關(guān)不良反應(yīng)。結(jié)果 (1)主要終點(diǎn)指標(biāo)三聯(lián)方案CR率優(yōu)于兩聯(lián)方案(P0.05)。次要指標(biāo)AP和DP的CR率比較,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05);(2)三聯(lián)方案較兩聯(lián)方案的第一次嘔吐發(fā)生時(shí)間晚(P0.05);每例FLIE量表大于108分表示對(duì)生活質(zhì)量無影響,兩組差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(3)阿瑞匹坦的相關(guān)不良反應(yīng)主要為上腹脹痛或便秘。結(jié)論三聯(lián)止吐方案在中高度催吐性化療方案分次用藥所致惡心嘔吐防治中療效較好,安全可耐受。
[Abstract]:Objective to compare the efficacy and safety of neurokinin-1 receptor inhibitor Aripitan triple regimen and traditional two-regimen in the prevention of nausea and vomiting induced by moderate and high degree of emetic chemotherapy. Methods the data of 102 patients with chemotherapy were analyzed in a prospective controlled study. 49 patients were treated with 5-hydroxytryptamine 3 receptor inhibitor combined with tropisetron. 53 patients were treated with the triple antiemetic regimen of neurokinin-1 receptor inhibitor Aripitan combined with 5-hydroxytryptamine 3 receptor inhibitor and tropisetron. KaplanMeier curve was used to compare the time of first vomiting, FLIE scale was used to evaluate the quality of life of nausea and vomiting, and the related adverse reactions of aripitan were evaluated. Results (1) the CR rate of the triple regimen was better than that of the two schemes (P0.05). The CR rate of AP and DP were significantly different (P0.05); (2). The time of first vomiting in triple regimen was later than that in two groups (P0.05). There was no significant difference in quality of life between the two groups (P0.05). (3). The related adverse reactions of Arepitan were epigastric flatulence or constipation. Conclusion the triple antiemetic regimen is safe and tolerable in the prevention and treatment of nausea and vomiting caused by the moderate and high degree of emetic chemotherapy.
【作者單位】： 鄂爾多斯市中心醫(yī)院腫瘤科;
【分類號(hào)】：R730.53

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