【摘要】：目的探討腎臟甲狀腺濾泡樣腎細胞癌(thyroid-like follicular renal cell carcinoma)的臨床病理學特征、免疫表型及鑒別診斷。方法回顧性分析2例甲狀腺濾泡樣腎細胞癌的臨床病理學和影像學資料,將腫瘤標本行常規(guī)病理組織學和免疫組化檢查,并復習相關文獻。結果 2例患者均為女性,年齡分別為25、68歲,臨床均以體檢時發(fā)現腎臟腫塊就診。腫瘤位于腎臟實質內,邊界較清楚。鏡下見腫瘤由大小不一的濾泡樣結構組成,濾泡腔內含嗜酸性膠質樣物。免疫表型:腫瘤細胞CK廣譜、CK7、EMA彌漫強陽性,CD10散在弱陽性,RCC、TTF-1、TG、AMACR、NSE、Syn和Cg A均陰性。結論腎臟甲狀腺濾泡樣腎細胞癌是一種罕見的、低度惡性潛能的腎上皮來源的腫瘤,WHO(2016)將其列為腎細胞癌的暫定亞型。確診主要依賴特征性的組織學表現(內含膠質樣物的濾泡結構),預后可能有別于其他腎細胞癌類型。臨床病理醫(yī)師應提高認識水平,避免誤診、誤治。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype and differential diagnosis of renal follicular renal cell carcinoma (thyroid-like follicular renal cell carcinoma). Methods the clinicopathological and imaging data of 2 cases of thyroid follicular renal cell carcinoma were analyzed retrospectively. Results the two patients were all female, aged 25 to 68 years. All the patients were diagnosed with renal mass at the time of physical examination. The tumor is located in the renal parenchyma and the boundary is clear. Microscopically, the tumor was composed of follicle-like structure of different size, and the acidophilic colloid was found in the follicular cavity. Immunophenotypes: tumor cell CK broad spectrum, CK7,EMA diffuse strong positive, CD10 scattered weakly positive, RCC,TTF-1,TG,AMACR,NSE,Syn and Cg A negative. Conclusion Renal follicular renal cell carcinoma (, WHO (2016) is a rare, low-grade malignant epithelial tumor that is classified as a provisional subtype of renal cell carcinoma. The diagnosis mainly depends on the characteristic histological features (the follicular structure containing glial substance) and the prognosis may be different from other renal cell carcinoma types. Clinicopathologists should improve their understanding and avoid misdiagnosis and mistreatment.
【作者單位】： 山東省東營市勝利油田中心醫(yī)院病理科;山東省臨朐縣人民醫(yī)院病理科;山東省東營市勝利油田中心醫(yī)院醫(yī)學影像科;浙江省紹興市人民醫(yī)院病理科;
【分類號】：R737.11

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