【摘要】：目的:比較非小細胞肺癌患者與正常體檢人群外周血相對端粒長度的差異,同時觀察端粒長度與非小細胞肺癌臨床特征的相關(guān)性。方法:選取2016年3月至2016年10月期間就診于蘭州軍區(qū)蘭州總醫(yī)院,經(jīng)肺部穿刺活檢或氣管鏡下活檢,病理結(jié)果顯示為非小細胞肺癌(腺癌、鱗癌、大細胞癌等),共70例患者,并選取同期體檢中心健康體檢者40例作為對照組,檢測非小細胞肺癌組及對照組外周血相對端粒長度的水平,同時統(tǒng)計非小細胞肺癌組的臨床分期、病理類型、Ki-67陽性細胞數(shù)表達水平等,運用SPSS19.0統(tǒng)計學軟件進行相關(guān)指標分析。結(jié)果:1.非小細胞肺癌組患者外周血相對端粒長度明顯高于健康對照組(P0.05)。2.非小細胞肺癌組外周血相對端粒長度與臨床分期相關(guān),分期越晚(Ⅲ+Ⅳ),端粒長度縮小越明顯(P0.05)。3.不同病理類型的非小細胞肺癌患者端粒長度不同,腺癌組較鱗癌組,端粒縮短更明顯(P0.05)。4.外周血端粒長度受病灶大小的影響,病灶越大,端�？s小越明顯(P0.05)。5.非小細胞肺癌組中,淋巴結(jié)是否轉(zhuǎn)移,端粒長度的變化無明顯差異(P0.05)。6.非小細胞肺癌組中,是否已出現(xiàn)遠處轉(zhuǎn)移對端粒長度的變化無影響(P0.05)。7.非小細胞肺癌組中,不同Ki-67陽性細胞數(shù)表達水平與端粒長度有明顯差異,Ki-67陽性細胞數(shù)表達水平越低,相對端粒長度越短(P0.05)。結(jié)論:1.非小細胞肺癌組的端粒長度較健康對照組明顯縮短,有望成為非小細胞肺癌早期診斷的生物標志物之一;2.端粒長度與非小細胞肺癌的臨床分期、病理類型、惡性程度密切相關(guān),有望作為新的腫瘤標記物或藥物治療靶點。
[Abstract]:Objective: to compare the relative telomere length in peripheral blood between patients with non-small cell lung cancer (NSCLC) and normal controls, and to observe the correlation between telomere length and clinical features of NSCLC. Methods: 70 patients with non-small cell lung cancer (adenocarcinoma, squamous cell carcinoma, large cell carcinoma, etc.) were selected from Lanzhou General Hospital of Lanzhou military region from March 2016 to October 2016. The relative telomere length of peripheral blood in non-small cell lung cancer (NSCLC) group and control group were measured, and the clinical stages and pathological types of NSCLC group were analyzed. The expression level of Ki-67 positive cells was analyzed by SPSS19.0 software. Results: 1. The relative telomere length of peripheral blood in non-small cell lung cancer group was significantly higher than that in healthy control group (P0.05). In non-small cell lung cancer group, the relative telomere length in peripheral blood was correlated with clinical stage. The later the stage (鈪，

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