【摘要】：目的： 探討乳腺癌患者CNB與OSB相比，其準(zhǔn)確性、影響準(zhǔn)確性的因素及對預(yù)后的影響。 方法： 回顧性分析吉林大學(xué)第一醫(yī)院1106例行手術(shù)治療的乳腺癌患者的臨床病理資料。根據(jù)術(shù)前診斷方法將其分為CNB組（n=553）和OSB組（n=553）。比較兩組間臨床病理信息、DFS和OS的差異。所有的統(tǒng)計數(shù)據(jù)以SPSS軟件進(jìn)行計算和分析。統(tǒng)計學(xué)結(jié)果以p0.05為差異有統(tǒng)計學(xué)意義。卡方檢驗用于分析計數(shù)資料的組間差異（必要時應(yīng)用Fisher精確檢驗）。COX比例風(fēng)險模型用于可能影響乳腺癌患者預(yù)后的單因素和多因素分析并以95%為可信區(qū)間。 結(jié)果： CNB診斷符合率為97.6%，病理檢出率為89.7%。以下幾種情況下，CNB病理診斷的符合率較低：腫物伴有鈣化，穿刺病理為導(dǎo)管內(nèi)癌、導(dǎo)管內(nèi)癌伴微小浸潤和非典型增生。與OSB組相比，CNB未增加患者局部復(fù)發(fā)率（P=0.363）�；顧z方式（CNB vs OSB）不作為影響患者DFS（P=0.087，95%CI：0.919~3.448）和OS（P=0.453，95%CI：0.627~2.848）的因素。活檢日期-手術(shù)日期間的間隔時間也不作為影響患者DFS（P=0.054，95%CI：0.353~1.008）和OS（P=0.223，95%CI：0.397~1.240）的因素。 結(jié)論： 術(shù)前空芯針穿刺活檢是一種安全可靠的術(shù)前診斷方式，值得臨床應(yīng)用與推廣。
[Abstract]:Objective: to investigate the accuracy, influencing factors and prognosis of CNB compared with OSB in breast cancer patients. Methods: the clinicopathological data of 1106 patients with breast cancer treated surgically in the first Hospital of Jilin University were analyzed retrospectively. According to the preoperative diagnosis method, the patients were divided into two groups: CNB group (NV 553) and OSB group (n = 553). The differences of clinicopathological information, DFS and OS were compared between the two groups. All statistics are calculated and analyzed by SPSS software. There was a significant difference in the statistical results between the two groups (p 0.05). Chi-square test was used to analyze the differences between groups of counting data (Fisher accurate test of). COX proportional risk model was used for univariate and multivariate analysis of breast cancer patients with 95% confidence interval when necessary. Results: the diagnostic coincidence rate of CNB was 97. 6% and the pathological detection rate was 89. 7%. The coincidence rate of pathological diagnosis of CNB was low: tumor with calcification, biopsy with ductal carcinoma, intraductal carcinoma with microinvasion and atypical hyperplasia. Compared with OSB group, CNB did not increase the local recurrence rate (P0. 363). (CNB vs OSB) was not a factor affecting DFS (P0. 087: 95) and OS (P0. 453 / 95 CI: 0. 627 / 2. 848) of the patient's DFS (P < 0. 087) and OS (P = 0. 453 / 95 CI: 0. 627 / 2. 848). The interval between biopsy date and operation day was also not a factor affecting the patient's DFS (P0.054 / 95) and OS (P0. 22395 CI: 0. 3971.240). Conclusion: preoperative hollow needle biopsy is a safe and reliable preoperative diagnostic method, and it is worthy of clinical application and popularization.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R737.9

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