【摘要】：目的:探討超敏C反應(yīng)蛋白(high sensitivity-C reactive protein,Hs-CRP)水平在外周T細胞淋巴瘤(peripheral T-cell lymphoma,PTCL)患者預(yù)后中的意義。方法:回顧性分析2005年1月1日至2016年12月31日浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院就診的初治PTCL患者247例,其中在隨訪過程中失訪13例,實際入組234例,患者中位年齡48歲;治療前檢測Hs-CRP水平,同時完善相關(guān)檢查以明確腫瘤分期及國際預(yù)后指數(shù)(international prognostic index,IPI),中位隨訪時間23個月,觀察Hs-CRP水平與患者總生存期(overall survival,OS)的關(guān)系。結(jié)果:Hs-CRP水平與IPI評分(r=0.132,P0.01)、Ann Arbor分期(r=0.183,P=0.005)、B癥狀(r=0.225,P=0.001)、乳酸脫氫酶(lactate dehydrogenase,LDH)(r=0.169,P=0.009)呈正相關(guān)(P0.05);與血漿白蛋白水平(r=-0.343,P0.001)、血紅蛋白濃度(r=-0.239,P0.001)、血小板計數(shù)(r=0.131,P=0.045)呈負相關(guān)(P0.05);與年齡、性別、體能(ECOG)評分、白細胞計數(shù)無顯著相關(guān)性(P0.05),血清Hs-CRP≤10 mg/L較Hs-CRP10 mg/L患者具有更好的OS(P0.05)。單因素分析及多因素Cox回歸模型顯示血小板計數(shù)、Hs-CRP、白蛋白水平、IPI評分是OS的獨立預(yù)后不良因素(P0.05)。結(jié)論:PTCL患者治療前血清Hs-CRP水平可以和IPI評分一樣作為PTCL預(yù)后的指標。
[Abstract]:Objective: to investigate the prognostic significance of high sensitivity C reactive protein (high sensitivity-C reactive protein,Hs-CRP) in peripheral T cell lymphoma (peripheral T-cell lymphoma,PTCL). Methods: from January 1, 2005 to December 31, 2016, 247 newly diagnosed PTCL patients in the first affiliated Hospital of Zhejiang University Medical College were retrospectively analyzed. Among them, 13 cases were lost during follow-up, and 234 cases were actually admitted to the group. The median age of the patients was 48 years old. The level of Hs-CRP was detected before treatment and the correlation examination was completed to determine tumor staging and international prognostic index (international prognostic index,IPI). The median follow-up time was 23 months. The relationship between Hs-CRP level and total survival (overall survival,OS) was observed. Results: the level of Hs-CRP and the IPI score (rn 0.132 鹵P0.01), Ann Arbor stage (r = 0.183), P ~ (0.005), B (r = 0.225), lactate dehydrogenase,LDH (r = 0.169), P < 0.05). P0. 009) positive correlation (P0.05); There was a negative correlation between plasma albumin level (r-0.344), hemoglobin concentration (r-0.239), platelet count (r-0.131) and platelet count (P 0.05). There was no significant correlation with age, sex, physical fitness (ECOG) score and white blood cell count (P0.05). Serum Hs-CRP 鈮，

本文編號：2356728