【摘要】：近年來發(fā)現(xiàn),JAK2-STAT3信號通路參與腫瘤細(xì)胞的生長、增殖、分化、轉(zhuǎn)移、凋亡。在肝細(xì)胞癌(HCC)細(xì)胞中的JAK蛋白和STAT蛋白過表達(dá),JAK2-STAT3信號通路與HCC發(fā)生發(fā)展密切相關(guān)。筆者就JAK2-STAT3信號通路在HCC的研究進(jìn)展做一綜述。
[Abstract]:In recent years, JAK2-STAT3 signaling pathway has been found to be involved in the growth, proliferation, differentiation, metastasis and apoptosis of tumor cells. Overexpression of JAK protein and STAT protein in hepatocellular carcinoma (HCC) cells, JAK2-STAT3 signaling pathway is closely related to the occurrence and development of HCC. This paper reviews the research progress of JAK2-STAT3 signaling pathway in HCC.
【作者單位】： 中南大學(xué)湘雅醫(yī)院衛(wèi)生部納米生物技術(shù)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81302075,81272193,81402001)
【分類號】：R735.7

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 Man-Hsin Hung;Wei-Tien Tai;Chung-Wai Shiau;Kuen-Feng Chen;;Downregulation of signal transducer and activator of transcription 3 by sorafenib:A novel mechanism for hepatocellular carcinoma therapy[J];World Journal of Gastroenterology;2014年41期

2 Bo Zhai;Xue-Ying Sun;;Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma[J];World Journal of Hepatology;2013年07期

3 張斌;鐘德s，

本文編號：2350178