【摘要】：目的探討不同絕經(jīng)狀態(tài)下中國女性BMI與乳腺癌發(fā)病的關系。方法計算機檢索Pub Med、EMBASE、萬方數(shù)據(jù)庫、維普數(shù)據(jù)庫、相關期刊論文(CNKI),收集國內(nèi)外2000年1月至2017年2月公開發(fā)表的關于中國女性不同體質(zhì)指數(shù)(BMI)分組與乳腺癌發(fā)病關系的研究文獻。應用Stata12.0進行Meta分析,在總體效應關系存在的基礎上,進行線性和非線性模型擬合,若未發(fā)現(xiàn)劑量反應關系,再進一步探討不同BMI對乳腺癌發(fā)病的截斷效應,采用Begg's檢驗評估發(fā)表偏倚。結果共納入8篇文獻,共103 141人。絕經(jīng)前組合并后的效應量RR值為1.10(95%CI:0.95~1.27),絕經(jīng)后組合并后的效應量RR值為1.52(95%CI:1.31~1.75),絕經(jīng)前、后均未發(fā)現(xiàn)劑量-反應關系(X~2=1.95,PLinearity=0.16;=2.02,PNonlinearity=0.57)。相對于參照組(18.5 kg/m~2BMI≤24kg/m~2),絕經(jīng)后超重人群(24kg/m~2BMI≤28kg/m~2)其乳腺癌發(fā)病風險RR值為1.33(95%CI:1.10~1.60),肥胖人群(BMI28 kg/m~2)為1.83(95%CI:1.46~2.29)。Begg's檢驗的Z=0.82,P=0.41,所納入分析的文獻不存在發(fā)表偏倚。結論在中國,BMI升高可增加絕經(jīng)后女性乳腺癌的發(fā)病風險,而在絕經(jīng)前女性人群中尚未發(fā)現(xiàn)此關聯(lián)。
[Abstract]:Objective to investigate the relationship between BMI and breast cancer in Chinese women with different menopausal status. Methods Pub Med,EMBASE, Wanfang database, Weipu database and (CNKI), database were searched by computer. From January 2000 to February 2017, the literature on the relationship between (BMI) grouping and breast cancer incidence in Chinese women was collected from January 2000 to February 2017. Stata12.0 was used for Meta analysis. On the basis of the overall effect relationship, linear and nonlinear models were fitted. If no dose-response relationship was found, the truncation effect of different BMI on breast cancer was further discussed. Publication bias was evaluated by Begg's test. Results A total of 103 141 people were included in 8 articles. The RR value of postmenopausal group was 1.10 (95%CI:0.95~1.27), the RR value of postmenopausal group was 1.52 (95%CI:1.31~1.75), and that of premenopausal group was 1.10 (95%CI:0.95~1.27). No dose-response relationship was found after the experiment. = 2.02 P nonlinearity 0.57). Compared with the control group (18. 5 kg/m~2BMI 鈮，

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