【摘要】：目的:分析治療前外周血血小板與絕對(duì)淋巴細(xì)胞計(jì)數(shù)比值(plateletlymphocyte ratio,PLR)與外周T細(xì)胞淋巴瘤非特指型(peripheral T cell lymphoma,unspecified,PTCL-U)患者臨床病理特征的相關(guān)性,并探討其在預(yù)后中的意義。方法:對(duì)天津醫(yī)科大學(xué)腫瘤醫(yī)院初診的163例PTCL-U患者的臨床資料及生存情況進(jìn)行回顧性分析。根據(jù)受試者工作特征(receiver operating characteristic,ROC)曲線的截?cái)嘀祵⒒颊叻譃榈蚉LR組(PLR170,80例)和高PLR組(PLR≥170,83例),分析治療前PLR與PTCL-U患者預(yù)后的關(guān)系。結(jié)果:163例PTCL-U患者中,低PLR組患者的5年總生存(overall survival,OS)率和無(wú)進(jìn)展生存(progression-free survival,PFS)率(76.3%和60.0%)均高于高PLR組(10.8%和8.4%,P值均0.05)。年齡、美國(guó)東部腫瘤協(xié)作組體力狀態(tài)(Eastern Cooperative Oncology Group performance status,ECOG PS)評(píng)分、B組癥狀、血清乳酸脫氫酶(lactate dehydrogenase,LDH)水平、血小板及PLR與PTCL-U患者的OS明顯相關(guān)(P值均0.01)。多因素分析結(jié)果顯示,年齡、血清LDH水平、血小板及PLR是PTCL-U患者預(yù)后的獨(dú)立影響因素(P值均0.05)。結(jié)論:治療前外周血PLR與PTCL-U患者的預(yù)后明顯相關(guān),高水平PLR提示PTCL-U患者的預(yù)后不良。
[Abstract]:Objective: to analyze the correlation between the ratio of platelet to absolute lymphocyte count (plateletlymphocyte ratio,PLR) in peripheral blood before treatment and the clinicopathological characteristics of patients with peripheral T cell lymphoma (peripheral T cell lymphoma,unspecified,PTCL-U). And to explore its significance in prognosis. Methods: the clinical data and survival status of 163 patients with PTCL-U in tumor Hospital of Tianjin Medical University were retrospectively analyzed. The patients were divided into low PLR group (PLR170,80 cases) and high PLR group (PLR 鈮，

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